Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas
Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas
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Dimericursones A 和 B：来自麻风树根皮的两种前所未有的六环二聚二萜类化合物。
DOI：
10.1039/c8ob02082e
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发表时间：
2018-10-07
影响因子：
3.2
通讯作者：
Wang, Cui-Fang
中科院分区：
文献类型：
--
作者：
Liu, Jie-Qing;Xu, Ying;Wang, Cui-Fang
从麻疯树的根皮中分离得到两个新的六环二聚二萜类化合物--二聚二萜A和B(1和2)。它们的结构通过广泛的光谱分析、电子圆二色谱计算和单晶X-射线衍射法确证。敌草酮B(2)对脂多糖诱导的RAW264.7巨噬细胞产生一氧化氮有明显的抑制作用，其IC50值为5.65μM。
Dimericursones A and B (1 and 2), two unprecedented hexacyclic dimeric diterpenoids, were obtained from the root barks of Jatropha curcas. Their structures were elucidated by extensive spectroscopic analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Dimericursone B (2) showed significant inhibition on nitric oxide production of lipopolysaccharide-induced RAW264.7 macrophages with IC50 values of 5.65 μM.