Clonal elimination of self reactive V beta 6+ T cells induced by H-2 products expressed on thymic radio-resistant components.
Clonal elimination of self reactive V beta 6+ T cells induced by H-2 products expressed on thymic radio-resistant components.
复制标题
胸腺抗辐射成分上表达的 H-2 产品诱导的自身反应性 V beta 6 T 细胞的克隆消除。
DOI：
10.1093/intimm/4.1.75
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发表时间：
1992
影响因子：
4.4
通讯作者：
Onoè,K
中科院分区：
文献类型：
--
作者：
Arase,H;Arase,N;Ogasawara,K;Good,RA;Onoè,K
本文研究了胸腺放射抗性细胞在Vβ6+T细胞克隆性消除中的作用。以往对异基因骨髓嵌合体的研究表明，胸腺中来自供体骨髓的放射敏感的I-E+细胞在V-β6+T细胞的克隆消除中发挥着主要作用。然而，我们可以证明，不仅胸腺骨髓来源的成分，而且那些抗辐射的成分(可能是胸腺上皮细胞)可能参与诱导自我反应性T细胞的克隆性消除。胸腺的H-2单倍型和呈递β-1a产物的细胞类型不同，V MLS6+T细胞的比例也不同，这可能是由于H-2产物与T细胞抗原受体的亲和力不同以及基质细胞表达的耐受性不同所致。
The role of thymic radio-resistant cells on clonal elimination of Vβ6+T cells that are reactive to minor lymphocyte stimulatory (Mls)-1aplus I-E antigens has been investigated. Previous studies with allogeneic bone marrow chimeras revealed that radio-sensitive I-E+cells derived from donor bone marrow in the thymus play a major role in the clonal elimination of Vβ6+T cells. However, we could show that not only the thymic bone marrow derived components but also the radio-resistant ones (presumably thymic epithelial cells) might be involved in induction of clonal elimination of the self-reactive T cells. The proportion of Vβ6+T cells present varied with the H-2 haplotype of the thymus and the cell types presenting Mls-1aproducts, which might be attributable to differences in the affinity of the H-2 products to T cell antigen receptors and differences In the amount of tolerogens expressed on the stromal cells.