PAR-4 as a possible new target for pancreatic cancer therapy.
PAR-4 as a possible new target for pancreatic cancer therapy.
复制标题
DOI：
10.1517/14728222.2010.487066
复制
发表时间：
2010-06
影响因子：
5.8
通讯作者：
Mohammad RM
中科院分区：
文献类型：
--
作者：
Azmi AS;Philip PA;Zafar SF;Sarkar FH;Mohammad RM
胰腺癌（PC）是一种致命的疾病，迄今为止对现有的治疗方案来说是难以治愈的。虽然在不同的肿瘤类型中有很好的描述，但凋亡诱导剂Par-4在PC中的重要性尚未得到认识。PC是一种致癌kras驱动的疾病，已知其下调Par-4。因此，这篇综述强调了它的重要性，并建立了一个强有力的案例，支持par4作为PC可能的治疗靶点的作用。这篇文章涵盖了基于文献的证据跨越过去15年的Par-4及其在PC中的意义。本综述全面了解了Par-4的重要性及其与PC中kras状态的关联，以及与关键耐药和存活分子NF-kB和Bcl-2的串串，这些串串最终导致了该疾病不同治疗方法的总体不良结果。par4有望成为一种潜在的治疗靶点，可以由化学预防剂和小分子抑制剂单独或与标准化疗药物联合诱导，导致PC细胞的选择性凋亡。它还可以作为化学增敏剂，因此值得对这种致命疾病进行进一步的临床研究。
Pancreatic cancer (PC) is a deadly disease that is so far intractable to currently available treatment regimens. Although well described in different tumors types, the importance of apoptosis inducer Par-4 in PC has not been appreciated. PC is a oncogenic kras driven disease which is known to down-regulate Par-4. Therefore, this review highlights its significance and builds a strong case supporting the role of Par-4 as a possible therapeutic target in PC. This article covers literature based evidence spanning the last 15 years on Par-4 and its significance in PC. This review provides comprehensive knowledge of the significance of Par-4 and its association with kras status in PC, along with the crosstalk with crucial resistance and survival molecules NF-kB and Bcl-2 that ultimately are responsible for the overall poor outcome of different therapeutic approaches in this disease. Par-4 holds promise as a potential therapeutic target that can be induced by chemopreventive agents and small molecule inhibitors either alone or in combination with standard chemotherapeutics leading to selective apoptosis in PC cells. It also acts as a chemosensitizer and therefore warrants further clinical investigations in this deadly disease.
登录
查看更多内容
影响因子：
8
作者：
Ni Chonghaile T;Letai A
通讯作者：
Letai A
影响因子：
5.7
作者：
Ali, Shadan;Banerjee, Sanjeev;Sarkar, Fazlul H.
通讯作者：
Sarkar, Fazlul H.
影响因子：
4.8
作者：
Cheema, SK;Mishra, SK;Lopez-Berestein, G
通讯作者：
Lopez-Berestein, G
影响因子：
8.8
作者：
Bramhall, SR;Schulz, J;Nemunaitis, J;Brown, PD;Baillet, M;Buckels, JAC
通讯作者：
Buckels, JAC
影响因子：
3.6
作者：
Evans, JD;Cornford, PA;Neoptolemos, JP
通讯作者：
Neoptolemos, JP