Identification of transposon-inserted mutations including rnpB:: Tn that abolished glucose induction of sigX encoding extracytoplasmic function-sigma factor in Bacillus subtilis
Identification of transposon-inserted mutations including rnpB:: Tn that abolished glucose induction of sigX encoding extracytoplasmic function-sigma factor in Bacillus subtilis
复制标题
鉴定转座子插入突变，包括 rnpB::Tn，其消除了枯草芽孢杆菌中编码胞质外功能 sigma 因子的 sigX 的葡萄糖诱导
DOI：
10.1093/bbb/zbab211
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Mitsuo Ogura
中科院分区：
文献类型：
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作者：
竹野谷 美穂子;平塚 孔章;伊藤 晋作;佐々木 康幸;矢嶋 俊介;Mitsuo Ogura
我们研究了ECF-sigmagenessigX/M的葡萄糖诱导（GI）的调节剂。在进一步筛选转座子插入突变体的过程中，我们鉴定了几种调节因子，包括tRNA成熟所需的RNase P（rnpB）的RNA成分。已知rnpB的缺失可触发严格反应。我们证明了严格反应抑制sigX/M的GI。
We investigated the regulators of the glucose induction (GI) of the ECF-sigma genessigX/M. During further screening of transposon-inserted mutants, we identified several regulators including an RNA component of RNase P (rnpB), which is required for tRNA maturation. A depletion ofrnpBis known to trigger the stringent response. We showed evidence that the stringent response inhibited GI ofsigX/M.