Megaloblastic changes in the cervical epithelium. Association with oral contraceptive therapy and reversal with folic acid.
Megaloblastic changes in the cervical epithelium. Association with oral contraceptive therapy and reversal with folic acid.
复制标题
宫颈上皮的巨幼细胞变化。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
J. Lindenbaum
中科院分区：
文献类型：
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作者：
N. Whitehead;F. Reyner;J. Lindenbaum
在115名服用口服避孕药（雌孕激素联合或仅孕激素）的妇女中，有22名（19%）发现了类似于严重叶酸和维生素B12缺乏症的宫颈阴道细胞“巨幼细胞”异常。在51名未服用这些药物的对照组中，没有观察到类似的变化。细胞学异常与血液学检查结果或血清叶酸和维生素B12浓度无关。所有8名患者接受药理剂量叶酸治疗3周后，这些变化恢复正常或明显改善。假设口服避孕药在终末器官水平诱导叶酸代谢的局部干扰。
"Megaloblastic" abnormalities of cervicovaginal cells similar to those seen in severe folate and vitamin B12deficiency were found in 22 (19%) of 115 women taking oral contraceptive agents (combined estrogen-progestogen or progestogens only). Similar changes were not observed in any of 51 controls not taking these medications. The cytologic abnormalities could not be related to hematologic findings or serum folate and vitamin B12concentrations. The changes reverted to normal or improved markedly in all eight patients treated with pharmacologic doses of folic acid for three weeks. It is hypothesized that oral contraceptive agents induce a localized interference with folate metabolism at the end organ level.