Neurobiology of Caenorhabditis elegans Locomotion: Where Do We Stand?
Neurobiology of Caenorhabditis elegans Locomotion: Where Do We Stand?
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DOI：
10.1093/biosci/biu058
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发表时间：
2014-06-01
期刊：
影响因子：
10.1
通讯作者：
Haspel G
中科院分区：
文献类型：
--
作者：
Gjorgjieva J;Biron D;Haspel G
动物在其生命周期的某个阶段使用神经系统进行运动。秀丽隐杆线虫是几乎所有实验生物学领域的主要动物模型，长期以来一直被用于遗传和生理运动机制的详细研究。在其959个体细胞中，有302个是神经元，可以通过谱系、位置、形态和神经化学在每个成年雌雄同体中识别。其中，75个运动神经元支配在运动过程中提供推力的体壁肌肉。在本概述中，我们集中在爬行和游泳过程中向前或向后运动的生成。我们描述了运动行为，组成运动系统的部分，以及相关的神经元连接。因为它还没有完全理解这些组件如何结合联合收割机产生运动，我们讨论竞争的假设和模型。
Animals use a nervous system for locomotion in some stage of their life cycle. The nematode Caenorhabditis elegans, a major animal model for almost all fields of experimental biology, has long been used for detailed studies of genetic and physiological locomotion mechanisms. Of its 959 somatic cells, 302 are neurons that are identifiable by lineage, location, morphology, and neurochemistry in every adult hermaphrodite. Of those, 75 motoneurons innervate body wall muscles that provide the thrust during locomotion. In this Overview, we concentrate on the generation of either forward- or backward-directed motion during crawling and swimming. We describe locomotion behavior, the parts constituting the locomotion system, and the relevant neuronal connectivity. Because it is not yet fully understood how these components combine to generate locomotion, we discuss competing hypotheses and models.