Asymmetric Conjugate Additions and Allylic Alkylations Using Nucleophiles Generated by Hydro- or Carbometallation
Asymmetric Conjugate Additions and Allylic Alkylations Using Nucleophiles Generated by Hydro- or Carbometallation
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DOI：
10.1002/chem.201405855
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发表时间：
2015-04-07
影响因子：
4.3
通讯作者：
Fletcher, Stephen P.
中科院分区：
文献类型：
--
作者：
Maksymowicz, Rebecca M.;Bissette, Andrew J.;Fletcher, Stephen P.
这篇小综述讨论了催化不对称共轭加成和烯丙基烷基化反应，其中亲核试剂是由氢化金属或碳代金属原位生成的。不对称催化的这一令人兴奋的最新趋势有望扩大可用于学术和工业研究的复杂功能分子的快速和选择性组装的转化范围。这篇小综述旨在为迄今为止报告的研究提供参考，并讨论这些过程的当前状态、范围和局限性。
This Minireview discusses catalytic asymmetric conjugate addition and allylic alkylation reactions where the nucleophiles were generated in situ by hydrometallation or carbometallation. This exciting recent trend in asymmetric catalysis promises to expand the range of transformations available for the rapid and selective assembly of complex, functional molecules for both academic and industrial research. This Minireview aims to serve as a reference for studies reported to date and discusses the current state-of-theart, scope and limitations of these processes.