Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: A PET study with [F-18]deoxyglucose
Focal metabolic activation in the predominant left auditory cortex in patients suffering from tinnitus: A PET study with [F-18]deoxyglucose
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DOI：
10.1159/000276835
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发表时间：
1996-07-01
期刊：
影响因子：
--
通讯作者：
Schwaiger, M
中科院分区：
文献类型：
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作者：
Arnold, W;Bartenstein, P;Schwaiger, M
11名患有慢性致残性耳鸣的患者接受了FDG-PET研究（使用[F-18]脱氧葡萄糖的正电子发射断层扫描）。9例耳鸣患者显示左侧代谢活动显著增加，1例在右侧初级听觉皮层（PAC，Brodmann 41区）。这些结果与14名无耳鸣的健康对照者相比具有统计学意义。一个消极的结果是从慢性耳鸣患者，但谁没有主观的投诉期间PET调查。一名患者首先在禁用耳鸣期间进行了调查，后来在耳鸣缓解期间，再次遭受严重耳鸣。他的左PAC的代谢活动与每次PET检查中耳鸣主诉的主观程度一致。虽然这些结果第一次给出了耳鸣感觉和定位的客观证据，但由于结合联合收割机功能性脑成像和声刺激的研究数据有限，因此难以解释。
Eleven patients suffering from chronic disabling tinnitus underwent an FDG-PET study (positron emission tomography with [F-18]deoxyglucose). Nine tinnitus patients revealed a significantly increased metabolic activity in the left, 1 in the right primary auditory cortex (PAC, Brodmann area 41). These results were statistically significant when compared to 14 healthy control individuals without tinnitus. A negative result was obtained from a chronic tinnitus patient but who had no subjective complaints during the period of PET investigation. One patient was first investigated during a disabling tinnitus period, later during a period with tinnitus relief and again when suffering from severe tinnitus. The metabolic activity of his left PAC was in good accordance with the subjective degree of tinnitus complaints present during each PET investigation. Although for the first time these results give objective evidence of tinnitus sensation and localization, they are difficult to interpret because of the limited research data available that combine functional brain imaging and acoustic stimuli.