Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment
Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment
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DOI：
10.1017/s1041610208007631
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发表时间：
2008-12-01
影响因子：
7
通讯作者：
Forlenza, O. V.
中科院分区：
文献类型：
--
作者：
Pereira, F. S.;Yassuda, M. S.;Forlenza, O. V.
背景资料：先前的研究已经报道了老年人执行功能障碍和日常生活活动（ADL）能力之间的关联。本研究的目的是探讨执行功能和功能状态之间的关联在一个横截面的老年人与不同程度的cognitive impairment.Methods：89个人（平均年龄73.8岁）被招募在记忆诊所在圣保罗，巴西。受试者接受评估，并根据认知状况分为三个诊断组：正常对照组（NC，n = 32），轻度认知障碍组（MCI，n = 31）和轻度阿尔茨海默病组（AD，n=26）。执行功能与25项执行访谈（EXIT 25）进行了评估，并与功能状态测试（DAFS-R）的直接评估功能状态进行了测量。与非痴呆受试者相比，AD患者在EXIT 25中的表现显著较差，NC和MCI患者之间没有检测到显著差异。我们发现DAFS-R与EXIT 25评分之间存在稳健的负相关（r=-0.872，p < 0.001）。线性回归分析表明，一个显着的影响，EXIT-25和CAMCOG的DAFS-R scores.Conclusion：执行功能障碍和认知功能的一般措施下降与较低的能力进行工具性日常生活活动。MCI患者的功能状态比NC受试者差。MCI患者的功能状态可能会发生微妙的变化，这些变化只能通过ADL的客观测量来捕获。
Background: Previous studies have reported an association between executive dysfunction and the ability to perform activities of daily living (ADL)s among older adults. This study aims to examine the association between executive functions and functional status in a cross-section of older adults with varying degrees of cognitive impairment.Methods: 89 individuals (mean age 73.8 years) were recruited at a memory clinic in Sao Paulo, Brazil. Subjects underwent evaluation, and were allocated into three diagnostic groups according to cognitive status: normal controls (NC, n = 32), mild cognitive impairment (MCI, n = 3 1) and mild Alzheimer's disease (AD, n=26). Executive functions were assessed with the 25-item Executive Interview (EXIT25), and functional status was measured with the Direct Assessment of Functional Status test (DAFS-R).Results: Significantly different total DAFS-R scores were observed across the three diagnostic groups. Patients with AD performed significantly worse in EXIT25 compared with subjects without dementia, and no significant differences were detected between NC and MCI patients. We found a robust negative correlation between the DAFS-R and the EXIT25 scores (r=-0.872, p < 0.001). Linear regression analyses suggested a significant influence of the EXIT-25 and the CAMCOG on the DAFS-R scores.Conclusion: Executive dysfunction and decline in general measures of cognitive functioning are associated with a lower ability to undertake instrumental ADLs. MCI patients showed worse functional status than NC subjects. MCI patients may show subtle changes in functional status that may only be captured by objective measures of ADLs.