Cell-type-based model explaining coexpression patterns of genes in the brain
Cell-type-based model explaining coexpression patterns of genes in the brain
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DOI：
10.1073/pnas.1312098111
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发表时间：
2014-04-08
影响因子：
11.1
通讯作者：
Mitra, Partha P.
中科院分区：
文献类型：
--
作者：
Grange, Pascal;Bohland, Jason W.;Mitra, Partha P.
脊椎动物大脑中基因表达的空间模式不是独立的，因为成对的基因可以表现出复杂的共表达模式。两个基因可能在一个区域表达相似，但在其他区域表达差异。这些相关性已被定量研究，特别是成年小鼠大脑的艾伦图谱，但它们的生物学意义仍然模糊。我们提出了一个简单的模型的共表达模式的基本细胞类型的空间分布，并建立其可扩展性使用独立测量的细胞类型特异性转录组。该模型使我们能够预测小鼠大脑中细胞类型的空间分布。
Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-typespecific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.