Curcumin treatment protects rat retinal neurons against excitotoxicity:: effect on N-methyl-D-aspartate-induced intracellular Ca2+ increase
Curcumin treatment protects rat retinal neurons against excitotoxicity:: effect on N-methyl-D-aspartate-induced intracellular Ca2+ increase
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DOI：
10.1007/s00221-005-0068-0
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发表时间：
2005-12-01
影响因子：
2
通讯作者：
Malchiodi-Albedi, F
中科院分区：
文献类型：
--
作者：
Matteucci, A;Frank, C;Malchiodi-Albedi, F
姜黄素是一种从植物姜黄中提取的具有众所周知的抗氧化和抗炎活性的提取物，在大鼠视网膜培养物中测试其作为对抗兴奋性毒性的保护剂。用姜黄素处理24小时减少N-甲基- D-天冬氨酸（NMDA）介导的兴奋性毒性细胞损伤，估计为细胞活力的降低和凋亡的增加.这种保护作用与NMDA受体介导的Ca（2+）升高减少和NMDA受体磷酸化NR 1亚基水平降低有关。这些结果启发了一种新的药理作用的植物提取物，可能介导的NMDA受体活性的调制。
Curcumin, an extract from the plant Curcuma longa with well- known antioxidant and anti- inflammatory activities, was tested as protective agent against excitotoxicity in rat retinal cultures. A 24 h- treatment with curcumin reduced N- methyl- D- aspartate ( NMDA)mediated excitotoxic cell damage, estimated as decrease of cell viability and increase in apoptosis. The protection was associated with decrease of NMDA receptor- mediated Ca (2+) rise and reduction in the level of phosphorylated NR1 subunit of the NMDA receptor. These results enlighten a new pharmacological action of the plant extract, possibly mediated by a modulation of NMDA receptor activity.