Effect of NaCl on water activity and dynamics of protein hydration water dynamics in proteins by quasi-elastic neutron scattering
Effect of NaCl on water activity and dynamics of protein hydration water dynamics in proteins by quasi-elastic neutron scattering
复制标题
NaCl 对水活度和蛋白质水合动力学的影响 通过准弹性中子散射研究蛋白质中的水动力学
DOI：
10.1002/masy.202200071
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发表时间：
2022
影响因子：
--
通讯作者：
Hiroshi Nakagawa
中科院分区：
文献类型：
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作者：
Jeon Jihun;Doi Kiyotaka;Kim Hyung Do;Ogawa Hiroki;Takenaka Mikihito;Ohkita Hideo;小柳津研一;Hiroshi Nakagawa
NaCl对蛋白质水合作用的影响是食品科学和极端环境生物学等跨学科领域的研究热点。本文利用非相干准弹性中子散射（iQENS）研究了恒定水活度（Aw）下不同NaCl浓度下蛋白质的水化动力学。在相同温度下，随着NaCl浓度的增加，水的含量增加。对这些样品的iQENS分析表明，尽管含水量不同，但水分子动力学没有显著差异。这说明在NaCl的存在下，水化水动力学受到抑制。水分子动力学受到NaCl的影响，但与此无关，awvalue与水分子动力学之间存在普遍的相关性。
Effect of NaCl on a protein hydration is of interest in interdisciplinary fields such as food science and extreme environment biology. Here, the protein hydration water dynamics with various NaCl concentrations at a constant water activity(Aw) by incoherent quasielastic neutron scattering (iQENS) are examined. Under the sameAw, the water content increases with increasing NaCl concentration. iQENS analysis of these samples shows no significant difference in the dynamics of water molecules despite of the difference of water content. This suggests that the hydration water dynamics should be suppressed in the present of NaCl. Water dynamics is affected by NaCl, but independent of this, there is a universal correlation betweenAwvalues and water molecule dynamics.