Pyruvate kinase activation and lipoperoxidation after selective hepatic ischemia in Wistar rats.
Pyruvate kinase activation and lipoperoxidation after selective hepatic ischemia in Wistar rats.
复制标题
Wistar 大鼠选择性肝缺血后丙酮酸激酶激活和脂质过氧化。
DOI：
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复制
发表时间：
2006
影响因子：
1.1
通讯作者：
L. Leonardi
中科院分区：
文献类型：
--
作者：
I. Boin;O. C. E. Silva;Maria Elisa Jordani Souza;Ana Catarina Calado Santos;L. Leonardi
目的
PURPOSE
Hepatic ischemia and reperfusion can cause several problems in hepatic surgery. The aim of this study was to determine pyruvate kinase activation and lipid peroxidation after hepatic ischemia.
METHODS
Twenty-four Wistar rats were submitted to 90 minutes of selective liver ischemia and 15 minutes of reperfusion. Twelve animals were submitted to selective liver ischemia and reperfusion (Group A) and the other 12 were submitted to sham operation (Group B). After 15 minutes of reperfusion, the following parameters were measured: mean arterial pressure (MAP), alanine aminotransferase (ALT), glycemia (GLY), hepatic glycogen (GH), pyruvate kinase (PK) activation, hepatic glutathione (GSH) and malondialdehyde (MDA). Analysis of the results were made by the Student t-test and has been considered significant difference for p<0.05.
RESULTS
A and B were differents for all parameters analized.
CONCLUSION
The animals of group A showed reperfusion syndrome with a fall in MAP, activation of glycid metabolism through the glycolitic pathway and presence of lipid peroxidation compared to group B.
内皮细胞损伤的机制。
DOI：
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发表时间：
1991
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Ward,PA
通讯作者：
Ward,PA