Bimodality of 2-h plasma glucose distributions in whites - The Rancho Bernardo study
Bimodality of 2-h plasma glucose distributions in whites - The Rancho Bernardo study
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DOI：
10.2337/diacare.28.6.1451
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发表时间：
2005-06-01
期刊：
影响因子：
16.2
通讯作者：
Barrett-Connor, E
中科院分区：
文献类型：
--
作者：
Fan, JJ;May, SJ;Barrett-Connor, E
目的--一些研究显示2型糖尿病高发人群的葡萄糖分布呈双峰曲线，但在北方欧洲血统的白人中尚未报道双峰曲线。目前尚不清楚这种差异是否反映了糖尿病的低患病率，掩盖了第二种模式，或者意味着白人和非白人之间更根本的差异。我们通过研究老年白色patients.Research设计和方法的葡萄糖分布调查这个问题-糖尿病的研究进行了老年社区居住的白色居住。1984年至1987年间，南加州郊区社区的乳房。从2,326名年龄在23-92岁的老年白色男性和女性中收集了两小时血糖数据。调查双峰的葡萄糖分布，我们适合单峰和双峰正常模型2小时血糖浓度转换的Box-Cox家庭transformation.RESULTS -我们发现，双峰正常混合模型拟合的数据显着优于单峰偏态分布模型的性别和所有年龄组，除了那些80岁。分离两种模式的临界点一般在11.1- 13.6-mmol/lrange.CONCLUSIONS -双峰的葡萄糖分布在白人之间，结合以前的研究结果，表明这种现象可能是普遍的。与其他研究相比，我们研究中较小的第二种模式表明，白人具有糖尿病易感性，但可能需要更多的肥胖来证明这一点。预计糖尿病的流行可能影响包括白人在内的所有种族群体。
OBJECTIVE - Several studies have shown a bimodal curve in the distribution of glucose in populations with a high prevalence of type 2 diabetes, but bimodality has not been reported among whites of Northern European ancestry. It is not clear whether this difference reflects the lower prevalence of diabetes, obscuring a second mode, or implies a more fundamental difference between whites and nonwhites. We investigate this issue by studying glucose distributions in older white patients.RESEARCH DESIGN AND METHODS - A study of diabetes was conducted among older community-dwelling white reside. Tits of a suburban Southern California community between 1984 and 1987. Two-hour plasma glucose data were collected from 2,326 older white men and women aged 23-92. To investigate bimodality of glucose distributions, we fit unimodal and bimodal normal models to 2-h plasma glucose concentrations transformed by the Box-Cox family of transformations.RESULTS - We found that the bimodal normal mixture model fit the data significantly better than the unimodal skewed distribution model for both sexes and all age-groups except those 80 years. The cut points separating the two modes were generally within the 11.1- to 13.6-mmol/l range.CONCLUSIONS - The bimodality of glucose distributions among whites, combined with previous findings, indicates that this phenomenon may be universal. A smaller second mode in our study compared with other studies suggests that whites have diabetes susceptibility but may require more obesity to demonstrate it. With increasing obesity in the U.S., the predicted epidemic of diabetes may affect all ethnic groups including whites.