Angiogenesis and antiangiogenic strategies in pancreatic cancer.
Angiogenesis and antiangiogenic strategies in pancreatic cancer.
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DOI：
10.1385/ijgc:33:1:79
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发表时间：
2003-01-01
期刊：
影响因子：
--
通讯作者：
Berger, David H
中科院分区：
文献类型：
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作者：
Fisher, William E;Berger, David H
尽管在实体瘤的治疗方面取得了许多进展，但诊断患有胰腺癌的患者的预后仍然令人沮丧。胰腺癌的手术和非手术治疗的结果都非常令人失望，因为肿瘤倾向于转移，化疗未能在肿瘤内达到足够的水平，以及胰腺癌对细胞毒性剂的抗性。目前的化学治疗剂和放射治疗依赖于肿瘤细胞的快速分裂性质，并且受到其对正常细胞的细胞毒性作用的限制。由于需要利用正常细胞和恶性细胞之间的差异，导致对肿瘤新生血管形成过程的大量研究。目前正在开发通过抑制血管生成来阻断肿瘤生长和转移的新药。本文综述了血管生成的过程和抗血管生成的策略，特别强调胰腺癌。
Despite numerous advances in the treatment of solid tumors, the prognosis of patients diagnosed with pancreatic cancer remains dismal. Results of both surgical and non-surgical treatment for pancreatic cancer have been extremely disappointing because of the tumors propensity to metastasize, failure of chemotherapy to achieve adequate levels within the tumor, and resistance of pancreatic cancer to cytotoxic agents. Current chemotherapeutic agents and radiation treatments rely on the rapidly dividing nature of tumor cells and are limited by their cytotoxic effects on normal cells. The need to exploit the difference between normal and malignant cells has resulted in an enormous amount of research into the process of tumor neovascularization. New agents are currently being developed that block tumor growth and metastasis through inhibition of angiogenesis. This article reviews the process of angiogenesis and antiangiogenic strategies with a special emphasis on pancreatic cancer.