Minireview: stem cell contribution to ovarian development, function, and disease.
Minireview: stem cell contribution to ovarian development, function, and disease.
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DOI：
10.1210/en.2008-0458
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发表时间：
2008-09
期刊：
影响因子：
4.8
通讯作者：
J. Tilly;B. Rueda
中科院分区：
文献类型：
--
作者：
J. Tilly;B. Rueda
由于卵母细胞不仅可以在受精后产生胚胎，而且可以有效地将成体体细胞核重新编程为多能状态，因此人们对干细胞在卵巢生物学中的作用的大部分兴趣都集中在种系上。然而，最近的研究表明，成体干细胞也可能与正常卵巢功能的研究具有相当大的相关性。此外，干细胞功能障碍可能是卵巢癌和多囊卵巢综合征等疾病的基础或促成因素。我们的目标是更详细地探索这些概念，希望激发进一步的研究工作，以了解干细胞在哺乳动物雌性性腺的生理学和病理学中可能发挥的作用。
By virtue of the fact that oocytes not only serve to produce embryos after fertilization but also can effectively reprogram adult somatic cell nuclei to a pluripotent state, much of the interest in the role of stem cells in ovarian biology has been focused on the germline. However, very recent studies have revealed that somatic stem cells may also be of considerable relevance to the study of normal ovarian function. Furthermore, stem cell dysfunction may underlie or contribute to disease states such as ovarian cancer and polycystic ovary syndrome. Our objective is to explore these concepts in greater detail, with the hope of stimulating further research efforts into understanding what role stem cells may play in the physiology and pathology of the mammalian female gonads.