Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial
Blood pressure variability and outcome after acute intracerebral haemorrhage: a post-hoc analysis of INTERACT2, a randomised controlled trial
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DOI：
10.1016/s1474-4422(14)70018-3
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发表时间：
2014-04-01
期刊：
影响因子：
48
通讯作者：
Anderson, Craig S.
中科院分区：
文献类型：
--
作者：
Manning, Lisa;Hirakawa, Yoichiro;Anderson, Craig S.
背景：高血压是急性脑卒中的一个预后因素，但血压变异性也可能独立预测预后。我们评估了参与者的血压变异性的预后价值的INTERACT 2，一个开放标签的随机对照试验（ClinicalTrials.gov编号NCT 00716079）。方法INTERACT 2纳入2839例成人自发性脑出血（ICH）和高收缩压（150-220毫米汞柱），没有明确的适应症或禁忌症，早期强化治疗，以降低血压。参与者被随机分配到强化治疗组（目标收缩压
Background High blood pressure is a prognostic factor for acute stroke, but blood pressure variability might also independently predict outcome. We assessed the prognostic value of blood pressure variability in participants of INTERACT2, an open-label randomised controlled trial (ClinicalTrials.gov number NCT00716079).Methods INTERACT2 enrolled 2839 adults with spontaneous intracerebral haemorrhage (ICH) and high systolic blood pressure (150-220 mm Hg) without a definite indication or contraindication to early intensive treatment to reduce blood pressure. Participants were randomly assigned to intensive treatment (target systolic blood pressure