Clinical relevance of ion channels for diagnosis and therapy of cancer
Clinical relevance of ion channels for diagnosis and therapy of cancer
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DOI：
10.1007/s00232-005-0782-3
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发表时间：
2005-06-01
影响因子：
2.4
通讯作者：
Schönherr, R
中科院分区：
文献类型：
--
作者：
Schönherr, R
离子通道在细胞增殖中起着至关重要的作用，通道阻滞剂可以抑制癌细胞的生长。离子通道作为治疗靶点或预后生物标志物的概念越来越引起人们的兴趣，但缺乏有效和选择性的通道调节剂多年来一直阻碍着关键的验证。今天，关于人类离子通道基因的知识几乎是完整的，许多天然电流的分子相关性已经被确定。这一信息引发了一波实验结果，确定了与特定癌症类型相关的单个离子通道。目前癌症相关离子通道的模式并不是任意的，而是可以减少到每个离子通道家族中的少数几个成员。本综述旨在提供分子识别的离子通道的概述，这些离子通道可能与最常见的人类癌症类型相关。讨论了这些候选药物用于靶向癌症治疗或临床诊断的可能应用。
Ion channels have a critical role in cell proliferation and it is well documented that channel blockers can inhibit the growth of cancer cells. The concept of ion channels as therapeutic targets or prognostic biomarkers attracts increasing interest, but the lack of potent and selective channel modulators has hampered a critical verification for many years. Today, the knowledge of human ion channel genes is almost complete and molecular correlates for many native currents have already been identified. This information triggered a wave of experimental results, identifying individual ion channels with relevance for specific cancer types. The current pattern of cancer-related ion channels is not arbitrary, but can be reduced to few members from each ion channel family. This review aims to provide an overview of the molecularly identified ion channels that might be relevant for the most common human cancer types. Possible applications of these candidates for a targeted cancer therapy or for clinical diagnosis are discussed.