Choking deaths: the role of antipsychotic medication
Choking deaths: the role of antipsychotic medication
复制标题
窒息死亡：抗精神病药物的作用
DOI：
10.1192/bjp.183.5.446
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发表时间：
2003
影响因子：
10.5
通讯作者：
J. Barry
中科院分区：
文献类型：
--
作者：
David Ruschena;P. Mullen;S. Palmer;P. Burgess;S. Cordner;O. Drummer;C. Wallace;J. Barry
背景抗精神病药物会增加窒息的风险，这已被反复假定。目的在大量窒息死亡病例中检查这种关联。方法将因窒息而死亡的个人病例与记录与公共精神卫生服务接触的病例登记簿联系起来。对精神障碍的实际和预期发生率以及精神药物在死后血液样本中的存在进行了比较。结果：70名窒息而死的人中，有超过20倍的可能性曾因精神分裂症接受过治疗。他们也更有可能有过器质性精神综合征。接受硫利达嗪或锂的风险分别是预期的92倍和30倍。其他抗精神病药物和精神药物的比例并不高。结论精神分裂症患者死亡风险的增加可能是固有倾向和使用特定抗精神病药物的组合。器质性精神综合征患者窒息风险增加与神经功能受损的后果一致。
Background An increased risk of choking associated with antipsychotic medication has been repeatedly postulated. Aims To examine this association in a large number of cases of choking deaths. Method Cases of individuals who had died because of choking were linked with a case register recording contacts with public mental health services. The actual and expected rates of psychiatric disorder and the presence of psychotropic medication in post-mortem blood samples were compared. Results The 70 people who had choked to death were over 20 times more likely to have been treated previously for schizophrenia. They were also more likely to have had a prior organic psychiatric syndrome. The risk for those receiving thioridazine or lithium was, respectively, 92 times and 30 times greater than expected. Other antipsychotic and psychotropic drugs were not over-represented. Conclusions The increased risk of death in people with schizophrenia may be a combination of inherent predispositions and the use of specific antipsychotic drugs. The increased risk of choking in those with organic psychiatric syndromes is consistent with the consequences of compromised neurological competence.