Infectious Mononucleosis at the United States Military Academy. A Prospective Study of a Single Class Over Four Years 1
Infectious Mononucleosis at the United States Military Academy. A Prospective Study of a Single Class Over Four Years 1
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美国军事学院的传染性单核细胞增多症。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
Voegtly jH
中科院分区：
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作者：
Hallee Tj;Evans As;Niederman Jc;Brooks Cm;Voegtly jH
1969年7月，在纽约州西点的美国军事学院，在1401名新生中开始了一项EB病毒感染的前瞻性研究。并持续了4年。入组时EBV抗体阳性率为63.5%，阴性率为36.5%。抗体流行率随学员来源的地理区域而变化。除了两名学员在第一次出血时已经患病外，没有临床传染性单核细胞增多症（I.M.）的证据。发生在4年期间，在890名学员进入学院与EB病毒抗体。在437名入学时没有抗体的学员中，54人或12.4%在大一时感染（血清转化）;其中15人有临床I. M，12人有暗示性的即时通讯39人没有已知的类似单核细胞增多症的疾病。敏感学员第二、三、四年的年感染率分别为24.4/100、15.1/100和30.8/100。201例4岁以上EB病毒感染者中，嗜异性阳性者仅占26.4%。总的来说，46%的437名学员进入没有EBV抗体成为感染超过40个月的血清学观察，明确的临床传染性单核细胞增多症的53名学员，临床发病率为12.1/100 4年。已知病例的暴露和易感室友中的EBV感染率并不高于未暴露的室友。EBV特异性IgM和总IgM的升高发生在急性期，并在后期恢复期消失。总IgG和伊加水平较不常见升高。EB病毒特异性IgM抗体在急性疾病期间可证实，但12个月后消失。不同ABO血型人群EB病毒感染率差异无统计学意义。
A prospective study of EB virus infections was initiated in July, 1969 in the entering class of 1401 cadets, at the U.S. Military Academy at West Point, N.Y. and continued over 4 yr. On entry 63.5% possessed EBV antibody and 36.5 lacked EBV antibody. The rate of antibody prevalence varied with the geographic area from which the cadet originated. Except in two cadets already ill on first bleeding no evidence of clinical infectious mononucleosis (I.M.) occurred over the 4 yr period in the 890 cadets entering the Academy with EBV antibody. Among 437 cadets without antibody on entry, 54 or 12.4% were infected (seroconverted) in the freshman year; 15 of these had clinical I.M., 12 had suggestive I.M., and 39 had no known mono-like illness. The annual infection rates in susceptible cadets in the second, third, and fourth years were 24.4, 15.1, and 30.8 per 100, respectively. Of 201 cadets infected with EBV over 4 yr only 26.4% were manifested by heterophile positive clinical infectious mononucleosis. Overall, 46% of the 437 cadets entering without EBV antibody became infected over 40 mo of serologic observation; definite clinical infectious mononucleosis developed in 53 cadets, a clinical attack rate of 12.1 per 100 for 4 yr. The EBV infection rate among exposed and susceptible roommates of known cases was no higher than in roommates not so exposed. Elevations of EBV-specific and total IgM occurred during acute illness and disappeared in late convalescence. Total IgG and IgA levels were less commonly elevated. EBV-specific-IgM antibody was demonstrable during the acute illness but was absent 12 mo later. Analysis of EBV infection rates revealed no difference among persons of different ABO blood groups.