Clinical profile of astemizole. A survey of 50 double-blind trials.
Clinical profile of astemizole. A survey of 50 double-blind trials.
复制标题
阿司咪唑的临床概况。
DOI：
--
复制
发表时间：
1987
期刊：
影响因子：
--
通讯作者：
N. Rombaut
中科院分区：
文献类型：
--
作者：
G. Vanden Bussche;M. Emanuel;N. Rombaut
根据超过 2,800 名患者的临床药理学和临床数据，阿司咪唑似乎是一种非常有效且耐受性良好的抗组胺药。对于缓解鼻炎，特别是鼻漏和打喷嚏，它优于安慰剂和常用的抗组胺药。它对结膜炎引起的眼部瘙痒和流泪以及荨麻疹引起的瘙痒和风团有显着效果。这种优势归因于非常特异、几乎完全且持续的组胺 H1 阻断。临床数据证实了其缺乏镇静作用的实验数据。
From clinical-pharmacologic and clinical data involving over 2,800 patients, astemizole appears to be a very effective and well-tolerated antihistamine. It is superior to placebo and commonly used antihistamines for the relief of rhinitis, particularly rhinorrhea and sneezing. It has a pronounced effect on ocular itching and lacrimation in conjunctivitis and on pruritus and wheals in urticaria. This superiority is due to a very specific, almost complete and sustained histamine H1-blockade. The clinical data confirm the experimental data in relation to its lack of sedative effects.