LESIONS OF THE CENTRAL NUCLEUS OF THE AMYGDALA BLOCK CONDITIONED EXCITATION, BUT NOT CONDITIONED INHIBITION OF FEAR AS MEASURED WITH THE FEAR-POTENTIATED STARTLE EFFECT
LESIONS OF THE CENTRAL NUCLEUS OF THE AMYGDALA BLOCK CONDITIONED EXCITATION, BUT NOT CONDITIONED INHIBITION OF FEAR AS MEASURED WITH THE FEAR-POTENTIATED STARTLE EFFECT
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DOI：
10.1037/0735-7044.109.3.379
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发表时间：
1995-06-01
影响因子：
1.9
通讯作者：
DAVIS, M
中科院分区：
文献类型：
--
作者：
FALLS, WA;DAVIS, M
在中度或广泛的光+电击训练后，杏仁核的损伤会阻止恐惧增强的惊吓的表达。本实验评估了杏仁核的损伤是否也会阻碍恐惧条件抑制的表达。对大鼠进行条件抑制训练，其中光与电击配对，在没有电击的情况下呈现噪音和光的化合物。然后对一半大鼠进行双侧杏仁核电解损伤，其余大鼠进行假手术。杏仁核的损伤阻断了对光线的恐惧增强惊吓的表达。为了评估条件抑制是否被破坏，大鼠在没有进一步条件抑制训练的情况下再接受光+电击配对训练。杏仁核受损的大鼠重新获得了对光线的恐惧增强惊吓（Kim和Davis， 1993）。重要的是，噪声条件抑制剂保留了对重新训练的光抑制恐惧增强惊吓的能力。这些结果表明，对恐惧增强惊吓的初始表现至关重要的杏仁核区域对条件抑制的表达并不重要。
Lesions of the amygdala block the expression of fear-potentiated startle following either moderate or extensive light + shock training. The present experiment assessed whether lesions of the amygdala would also block the expression of conditioned inhibition of fear. Rats were given conditioned inhibition training in which a light was paired with shock and a noise and light compound was presented in the absence of shock. Then half of the rats were given bilateral electrolytic lesions of the amygdala and the remaining rats were sham operated. Lesions of the amygdala blocked the expression of fear-potentiated startle to the light. To assess whether conditioned inhibition was disrupted, rats were retrained with light + shock pairings with no further conditioned inhibition training. Amygdala lesioned rats reacquired fear-potentiated startle to the light (Kim and Davis, 1993). Importantly, the noise conditioned inhibitor retained its ability to inhibit fear-potentiated startle to the retrained light. These results indicate that areas of the amygdala critical for initial performance of fear-potentiated startle are not critical for the expression of conditioned inhibition.