Infantile Stage M Neuroblastoma With 11q Deletion, Mimicking Stage MS
Infantile Stage M Neuroblastoma With 11q Deletion, Mimicking Stage MS
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DOI：
10.1097/mph.0000000000002398
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发表时间：
2022-04-01
影响因子：
1.2
通讯作者：
Shichino，Hiroyuki
中科院分区：
文献类型：
--
作者：
Suzuki，Yuri Yoshimoto;Yamanaka，Junko;Shichino，Hiroyuki
一名4个月大的男孩出现腹胀，被诊断出患有肾上腺神经母细胞瘤，并伴有多处肝脏转移以及皮肤和肌肉结节。随着肿瘤标志物水平的降低，明显的肝肿大自然消退，根据放射学检查结果证实胰腺转移，最终诊断为 M 期。神经母细胞瘤没有 MYCN 扩增，但有 11q 畸变。 6 个月大时开始化疗并取得成功反应。我们的病例反映了神经母细胞瘤的异质性临床行为，并强调了婴儿 M 期和 MS 期神经母细胞瘤之间差异的挑战性问题。
A 4-month-old boy with abdominal distension was diagnosed with adrenal neuroblastoma with numerous metastases to the liver and nodules in the skin and muscles. Marked hepatomegaly spontaneously regressed with decreasing tumor marker levels, and the final diagnosis was stage M based on radiologic findings confirming metastasis to the pancreas. The neuroblastoma did not have the MYCN amplification but had an 11q aberration. Chemotherapy was initiated at age 6 months with a successful response. Our case reflects the heterogenous clinical behavior of neuroblastoma and highlights the challenging issue of the difference between stage M and stage MS neuroblastoma in infants.