Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults.
Dietary inflammatory index and risk of upper aerodigestive tract cancer in Japanese adults.
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DOI：
10.18632/oncotarget.25288
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发表时间：
2018-05-08
期刊：
影响因子：
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通讯作者：
Matsuo K
中科院分区：
文献类型：
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作者：
Abe M;Shivappa N;Ito H;Oze I;Abe T;Shimizu Y;Hasegawa Y;Kiyohara C;Nomura M;Ogawa Y;Hebert JR;Matsuo K
饮食的潜在炎症已被证明与癌症风险有关。在日本的一项病例对照研究中，我们研究了通过饮食炎症指数（DII®）测量的饮食炎症潜力与上呼吸道消化道癌症风险之间的关系。观察到DII评分增加与总体上呼吸道消化道癌症和跨解剖亚位之间存在正相关。对于上消化道癌症，ORQ4vsQ1 = 1.73 (95% CI: 1.37-2.20)；头颈癌，ORQ4vsQ1为1.92 (95% CI: 1.42-2.59)；食管癌的ORQ4vsQ1为1.71 （95% CI: 1.54-1.90）。下咽癌和鼻咽癌的风险显著升高：下咽癌的ORQ4vsQ1 = 4.05 (95% CI: 1.24-13.25)，鼻咽癌的ORQ4vsQ1 = 4.99 （95% CI: 1.14-21.79）。在考虑了重要的混杂因素后，更促炎的饮食与上呼吸道消化道癌症的风险增加有关。除喉部外，所有解剖亚位均随DII评分升高而升高。那些已知与持续感染有病原学关联的亚位点显示出最大的风险升高。这些结果值得在未来的研究中进一步评估。这是一项在爱知癌症中心招募的1028例病例和3081例年龄和性别匹配的非癌症对照的病例对照研究。DII分数是根据自我管理的食物频率问卷对宏观和微量营养素的估计来计算的。分数进一步分为四分位数（基于对照组的分布）。拟合条件logistic回归模型来估计吸烟、酒精消耗、酒精冲洗、牙齿数量和职业组校正后的比值比（OR）和95%置信区间（ci）。
The inflammatory potential of diet that has been shown to be associated with cancer risk. We examined the association between dietary inflammatory potential as measured by the dietary inflammatory index (DII®) and risk of upper aerodigestive tract cancers in a Japanese case-control study. A positive association was observed between increasing DII scores and overall upper aerodigestive tract cancers, and across anatomic subsites. For upper aerodigestive tract cancers, the ORQ4vsQ1 = 1.73 (95% CI: 1.37–2.20); head and neck cancer, the ORQ4vsQ1 was 1.92 (95% CI: 1.42–2.59); and for esophageal cancer, the ORQ4vsQ1 was1.71 (95% CI: 1.54–1.90). Risks for hypopharyngeal and nasopharyngeal cancers were greatly elevated: (ORQ4vsQ1 = 4.05 (95% CI: 1.24–13.25) for hypopharyngeal cancer and ORQ4vsQ1 = 4.99 (95% CI: 1.14–21.79) for nasopharyngeal cancer. A more pro-inflammatory diet was associated with an elevated risk of upper aerodigestive tract cancers after accounting for important confounders. All anatomic subsites, except larynx, showed the consistently elevated risk with increasing DII score. Those subsites with known etiological associations with persistent infection showed the largest elevation in risk. These results warrant further evaluation in future studies. This is a case-control study of 1,028 cases and 3,081 age- and sex-matched non-cancer controls recruited at Aichi Cancer Center. DII scores were computed based on estimates of macro- and micro-nutrients from a self-administered food frequency questionnaire. Scores were further categorized into quartiles (based on the distribution in controls). Conditional logistic regression models were fit to estimate odds ratio (OR) and 95% confidence intervals (CIs) adjusted for smoking, ethanol consumption, alcohol flushing, number of teeth, and occupation group.