Health risk assessment on dietary exposure to polycyclic aromatic hydrocarbons (PAHs) in Taiyuan, China
Health risk assessment on dietary exposure to polycyclic aromatic hydrocarbons (PAHs) in Taiyuan, China
复制标题
中国太原市膳食中多环芳烃（PAHs）暴露健康风险评估
DOI：
10.1016/j.scitotenv.2010.08.008
复制
发表时间：
2010-10-15
影响因子：
9.8
通讯作者：
Hu, Xinxin
中科院分区：
文献类型：
--
作者：
Xia, Zhonghuan;Duan, Xiaoli;Hu, Xinxin
2008年12月对7类25种食品进行了抽样检测，测定了16种多环芳烃（PAHs）的浓度。猪肉中检测到的总多环芳烃含量最高（195.30 纳克/克），而牛奶中检测到的总多环芳烃含量最低（8.73 纳克/克）。男性儿童、青少年、成人和老年人的 B[a]P 当量（B[a]P(eq)）日暴露剂量中值分别为 392.42、511.01、571.56 和 532.56 ng/d，而上述人群女性的 B[a]P 当量（B[a]P(eq)）日暴露剂量中值分别为 355.16、440.51、487.64 和 分别为 444.85 纳克/天。男性儿童、男性青少年、男性成人、男性老年人、女性儿童、女性青少年、女性成人和女性老年人的第22.1、26.1、12.7、24.9、22.7、27.0、12.9和25.5百分位数的终生癌症增量风险(ILCR)值分别大于10(-6)，表明具有较高的潜力致癌风险， 上述组别在第 74.5、78.7、60.6、77.4、75.3、79.5、60.8 和 77.9 个百分位处均大于 10(-4)，这意味着存在显着的癌症风险。敏感性分析发现，口腔癌苯并芘斜率因子（SF）和每日膳食PAH暴露水平（ED）两个变量对ILCR的影响大于体重（BW）。 (C) 2010 Elsevier B.V. 保留所有权利。
Twenty-five kinds of seven categories of foods were sampled in December 2008 and the concentrations of 16 polycyclic aromatic hydrocarbons (PAHs) were determined. The highest level of total PAHs was detected in pork (195.30 ng/g) whereas the lowest concentration was found in milk (8.73 ng/g). The median values of B [a]P equivalent (B[a]P(eq)) daily exposure doses for children, adolescents, adults and seniors of male were estimated to be 392.42, 511.01, 571.56 and 532.56 ng/d, respectively, whereas those for the above population groups of female were found to be 355.16, 440.51, 487.64 and 444.85 ng/d, respectively. The incremental lifetime cancer risk (ILCR) values at the 22.1th, 26.1th, 12.7th, 24.9th, 22.7th, 27.0th, 12.9th, and 25.5th percentiles for male children, male adolescents, male adults, male seniors, female children, female adolescents, female adults and female seniors, respectively, were larger than 10(-6), indicating high potential carcinogenic risk, and were larger than 10(-4) at the 74.5th, 78.7th, 60.6th, 77.4th, 75.3th, 79.5th, 60.8th and 77.9th percentiles for the above groups, respectively, which implied significant cancer risk. Sensitivity analysis found that the two variables of oral cancer slope factor of benzo(a) pyrene (SF) and the daily dietary PAH exposure level (ED) had the greater impact than that of body weight (BW) on the ILCR. (C) 2010 Elsevier B.V. All rights reserved.