Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
Effects of an inhibitor of cholesteryl ester transfer protein on HDL cholesterol
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DOI：
10.1056/nejmoa031766
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发表时间：
2004-04-08
影响因子：
158.5
通讯作者：
Rader, DJ
中科院分区：
文献类型：
--
作者：
Brousseau, ME;Schaefer, EJ;Rader, DJ
背景：高密度脂蛋白（HDL）胆固醇水平降低是冠心病的主要危险因素；然而，没有任何疗法可以显着提高高密度脂蛋白胆固醇水平。抑制胆固醇酯转移蛋白 (CETP) 已被提议作为提高 HDL 胆固醇水平的策略。 方法：我们进行了一项单盲、安慰剂对照研究，以检查 Torcetrapib（一种有效的 CETP 抑制剂）对 19 名低 HDL 胆固醇受试者血浆脂蛋白水平的影响（
BACKGROUND:Decreased high-density lipoprotein (HDL) cholesterol levels constitute a major risk factor for coronary heart disease; however, there are no therapies that substantially raise HDL cholesterol levels. Inhibition of cholesteryl ester transfer protein (CETP) has been proposed as a strategy to raise HDL cholesterol levels.METHODS:We conducted a single-blind, placebo-controlled study to examine the effects of torcetrapib, a potent inhibitor of CETP, on plasma lipoprotein levels in 19 subjects with low levels of HDL cholesterol (