The Immunosuppressive Properties of Mesenchymal Stem Cells
The Immunosuppressive Properties of Mesenchymal Stem Cells
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DOI：
10.1097/tp.0b013e3181a285b0
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发表时间：
2009-05-15
期刊：
影响因子：
6.2
通讯作者：
Dazzi, Francesco
中科院分区：
文献类型：
--
作者：
Siegel, Georg;Schaefer, Richard;Dazzi, Francesco
间充质干细胞（MSC）是一种多能祖细胞，最初从骨髓中分离出来。除了多谱系分化和参与造血生态位外，它们还发挥强大的免疫调节作用，包括抑制 T 细胞、B 细胞和自然杀伤细胞的增殖和功能。这些独特的特性使得 MSC 在组织工程和免疫抑制的临床应用中引起了极大的兴趣。 MSC 介导的免疫调节机制的基础是非特异性抗增殖作用，这是细胞周期蛋白 D2 抑制的结果。特别令人感兴趣的是间充质干细胞影响其靶细胞的分子机制。该领域已经进行了多项研究，目前的数据表明吲哚胺 2,3-双加氧酶、前列腺素 E2、一氧化氮、组织相容性位点抗原-G、胰岛素样生长因子结合蛋白和耐受性抗原呈递细胞的作用。了解这些机制对于未来 MSC 在研究和临床应用中的使用至关重要。
Mesenchymal stem cells (MSC) are a type of multipotent progenitor cell, originally isolated from the bone marrow. In addition to multilineage differentiation and participation in the hematopoietic niche, they exert powerful immunomodulatory effects, which include inhibition of proliferation and function of T cells, B cells, and natural killer cells. These unique properties make MSC of great interest for clinical applications in tissue engineering and immunosuppression. Underlying the MSC-mediated immunomodulatory mechanisms is a nonspecific antiproliferative effect, which is the consequence of cyclin D2 inhibition. Of special interest are the molecular mechanisms, by which MSC influence their target cells. Several studies have been conducted in this field, and the current data suggest roles for indoleamine 2,3-dioxygenase, prostaglandin E2, nitric oxide, histocompatibility locus antigen-G, insulin-like growth factor-binding proteins, and tolerogenic antigen-presenting cells. Understanding these mechanisms is crucial for future use of MSC in research and clinical applications.