Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI: Comparison to standard of care.
Cerebral blood volume mapping with ferumoxytol in dynamic susceptibility contrast perfusion MRI: Comparison to standard of care.
复制标题
在动态磁敏感对比灌注 MRI 中使用费鲁莫托进行脑血容量测绘：与护理标准的比较。
DOI：
10.1002/jmri.25943
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Neuwelt,EdwardA
中科院分区：
文献类型：
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作者：
Varallyay,CsanadG;Nesbit,Eric;Horvath,Andrea;Varallyay,Peter;Fu,Rongwei;Gahramanov,Seymur;Muldoon,LeslieL;Li,Xin;Rooney,WilliamD;Neuwelt,EdwardA
BackgroundCerebral blood volume (CBV) mapping with a dynamic susceptibility contrast (DSC) perfusion technique has become a clinical tool in diagnosing and follow‐up of brain tumors. Ferumoxytol, a long‐circulating iron oxide nanoparticle, has been tested for CBV mapping, but the optimal dose has not been established.PurposeTo compare ferumoxytol DSC of two different doses to standard of care gadoteridol by analyzing time–intensity curves and CBV maps in normal‐appearing brain regions.Study TypeRetrospective.SubjectsFifty‐four patients with various brain disorders.Field Strength/Sequence3T MRI. DSC‐MRI was performed with 0.1 mmol/kg gadoteridol and 1 day later with ferumoxytol in doses of 1 or 2 mg/kg.AssessmentSignal changes during first pass, relative CBV (rCBV) in normal‐appearing thalamus, putamen, and globus pallidus, and contrast‐to‐noise ratio (CNR) of the CBV maps were compared between gadoteridol and various doses of ferumoxytol using an automated method. To subjectively assess the quality of the CBV maps, two blinded readers also assessed visual conspicuity of the putamen.Statistical TestsLinear mixed effect model was used for statistical comparison.ResultsCompared to gadoteridol, 1 mg/kg ferumoxytol showed no difference in CNR (P= 0.6505), peak ΔR2*, and rCBV in the putamen (P= 0.2669, 0.0871) or in the thalamus (P= 0.517, 0.9787); 2 mg/kg ferumoxytol increased peak ΔR2* as well as the CNR (P< 0.0001), but also mildly increased rCBV in putamen and globus pallidus (P= 0.0005, 0.0012). Signal intensities during first pass remained highly above the noise level, with overlapping of 95% confidence intervals with noise only in 3 out of 162 tested regions. Compared to gadoteridol, the visual image quality showed mild improvement with 1 mg/kg (P= 0.02) and marked improvement with 2 mg/kg ferumoxytol (P< 0.0001).Data Conclusion1 mg/kg ferumoxytol provides similar imaging results to standard gadoteridol for DSC‐MRI, and 2 mg/kg has a benefit of increased CNR, but may also result in mildly increased rCBV values.Level of Evidence:3Technical Efficacy:Stage 1J. MAGN. RESON. IMAGING 2018;48:441–448.
