Harnessing the beneficial heterologous effects of vaccination
Harnessing the beneficial heterologous effects of vaccination
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DOI：
10.1038/nri.2016.43
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发表时间：
2016-06-01
影响因子：
100.3
通讯作者：
Wilson, Christopher B.
中科院分区：
文献类型：
--
作者：
Goodridge, Helen S.;Ahmed, S. Sohail;Wilson, Christopher B.
临床证据有力地表明，某些活疫苗，特别是卡介苗和麻疹疫苗，可以降低全因死亡率，最有可能的是通过除了靶向病原体外，还对非靶向病原体提供保护。其潜在机制目前尚不清楚。我们讨论了异源淋巴细胞激活和先天免疫记忆如何促进保护超出预期的目标病原体，并考虑疫苗学家如何利用异源免疫来改善弱势群体的结果，特别是非常年轻和老年人。
Clinical evidence strongly suggests that certain live vaccines, in particular bacille Calmette-Guerin (BCG) and measles vaccines, can reduce all-cause mortality, most probably through protection against non-targeted pathogens in addition to the targeted pathogen. The underlying mechanisms are currently unknown. We discuss how heterologous lymphocyte activation and innate immune memory could promote protection beyond the intended target pathogen and consider how vaccinologists could leverage heterologous immunity to improve outcomes in vulnerable populations, in particular the very young and the elderly.