STRUCTURAL CONSIDERATIONS ON THE IRIDOIDS AS ANTIINFLAMMATORY AGENTS
STRUCTURAL CONSIDERATIONS ON THE IRIDOIDS AS ANTIINFLAMMATORY AGENTS
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DOI：
10.1055/s-2006-959465
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发表时间：
1994-06-01
期刊：
影响因子：
2.7
通讯作者：
RIOS, JL
中科院分区：
文献类型：
--
作者：
RECIO, MD;GINER, RM;RIOS, JL
在角叉菜胶诱导的小鼠足肿胀和TPA诱导的小鼠耳肿胀两种模型上评价了12种环烯醚萜苷的抗炎活性。马钱酸对前者的抑制作用最强（44.4%），而从玄参、桃叶珊瑚苷、马鞭草苷和马钱苷中分离的梓醇衍生物混合物对后者的抑制作用最强（72.0 - 80.0%）。结果使我们能够建立结构和抗炎活性之间的关系的基础上的不同模式的取代，特别是羟基化，不饱和，和酰化。
Twelve iridoid glycosides have been evaluated for their anti-inflammatory activity on two models: the carrageenan-induced mouse paw edema and the TPA-induced mouse ear edema. Loganic acid was the most active (44.4 % edema inhibition) on the former test, whereas the catalpol derivative mixture isolated fi om Scrophularia, aucubin, verbenalin, and loganin, showed the hightest activity (from 72.0 to 80.0% edema inhibition) on the latter. The results allowed us to establish the relationship between the structure and anti-inflammatory activity on the basis of the different patterns of substitution, particularly hydroxylation, unsaturation, and acylation.