CEST-FISP: a novel technique for rapid chemical exchange saturation transfer MRI at 7 T.
CEST-FISP: a novel technique for rapid chemical exchange saturation transfer MRI at 7 T.
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CEST-FISP：一种在7 t处的快速化学交换饱和转移MRI的新技术。
DOI：
10.1002/mrm.22637
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发表时间：
2011-02
影响因子：
3.3
通讯作者：
Flask, C. A.
中科院分区：
文献类型：
--
作者：
Shah, T.;Lu, L.;Dell, K. M.;Pagel, M. D.;Griswold, M. A.;Flask, C. A.
化学交换饱和转移（CEST）和磁化转移（MT）技术在多个MRI应用中提供了独特的定量对比度机制，但是，这些技术的体内实施受到了相对慢的MRI习得技术的限制MRI扫描仪。开发了一种新的CEST-FISP（CEST-稳态的快速成像）技术，可以在本研究中提供敏感的CEST对比度。与常规的CEST自旋回声获得相比，CEST-FISP技术的结果显示出等效的CEST灵敏度，并且降低了CEST-FISP技术的敏感性。取决于K-Space用中心的K空间进行编码，相对于256或更多K空间线的线性编码，CEST敏感性增加了30-40％。有可能提供定量的CEST和MT成像数据。
Chemical Exchange Saturation Transfer (CEST) and Magnetization Transfer (MT) techniques provide unique and potentially quantitative contrast mechanisms in multiple MRI applications. However, the in vivo implementation of these techniques has been limited by the relatively slow MRI acquisition techniques, especially on high field MRI scanners. A new, rapid CEST-FISP (CEST - Fast Imaging with Steady-state free Precession) technique was developed to provide sensitive CEST contrast in approximately 20 seconds. In this study at 7T with in vitro bovine glycogen samples and initial in vivo results in a rat liver, the CEST-FISP technique was shown to provide equivalent CEST sensitivity in comparison to a conventional CEST spin echo acquisition with a 50-fold reduction in acquisition time. The sensitivity of the CEST-FISP technique was also shown to be dependent on k-space encoding with centric k-space encoding providing a 30–40% increase in CEST sensitivity relative to linear encoding for 256 or more k-space lines. Overall, the CEST-FISP acquisition technique provides a rapid and sensitive imaging platform with the potential to provide quantitative CEST and MT imaging data.
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