Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: A pseudo-continuous arterial spin labeling (pCASL) study
Characteristic distributions of regional cerebral blood flow changes in major depressive disorder patients: A pseudo-continuous arterial spin labeling (pCASL) study
复制标题
DOI：
10.1016/j.jad.2014.04.032
复制
发表时间：
2014-08-20
影响因子：
6.6
通讯作者：
Kunugi, Hiroshi
中科院分区：
文献类型：
--
作者：
Ota, Miho;Noda, Takamasa;Kunugi, Hiroshi
背景资料：大多数以前的研究，检查局部脑血流量（rCBF）异常的重性抑郁症（MDD）需要注射放射性同位素到受试者。在这里，我们通过使用磁共振成像（MRI）与伪连续动脉自旋标记（pCASL）方法，不需要放射性同位素，我们检查了MDD患者的rCBF与精神分裂症患者和健康受试者相比，考虑到局部脑灰质体积。方法：受试者为27例MDD患者、42例精神分裂症患者和43例健康志愿者，均行pCASL 3-T MRI检查，所得pCASL成像数据进行逐体素统计分析。与健康对照组相比，MDD患者右下前额叶皮层和前扣带皮层（ACCs）的rCBF显著降低。与精神分裂症患者相比，MOD患者膝下ACC的rCBF较低，左枕区rCBF较高。结论：膝下区rCBF降低可能是MDD患者的一种特异性功能异常，可作为MDD的生物学标志物。MRI结合pCASL方法是一种有前途的工具，可用于检测控制灰质体积的rCBF异常。(C)2014爱思唯尔有限公司版权所有。
Background: Most previous studies that examined regional cerebral blood flow (rCBF) abnormalities in major depressive disorder (MDD) required the injection of radioisotopes into subjects. Here by using magnetic resonance imaging (MRI) with the pseudo-continuous arterial spin labeling (pCASL) method which does not require radioisotopes, we examined rCBF in patients with MDD in comparison with that in patients with schizophrenia and healthy subjects, taking the regional cerebral gray matter volume into account.Methods: Subjects were 27 patients with MDD, 42 with schizophrenia and 43 healthy volunteers who underwent 3-T MRI with pCASL Obtained pCASL imaging data were subject to the voxel-by-voxel statistical analysis.Results: There were significant reductions of rCBF in the right inferior prefrontal cortex and anterior cingulate cortices (ACCs) in the MDD patients compared with the healthy controls. When compared with the schizophrenic patients, the MOD patients showed lower rCBF in the subgenual ACC and higher rCBF in left occipital region.Limitation: The abnormalities of rCBF in MDD were known to reverse during symptom remission. Further study with follow-up period would bring the perception about the treatment response.Conclusion: The rCBF reduction in the subgenual region may be a specific functional abnormality to MDD patients, which may provide a biological marker for MOD. The MRI with pCASL method is a promising tool to detect rCBF abnormalities controlling for gray matter volume in psychiatric disorders. (C) 2014 Elsevier B.V. All rights reserved.