Cranial base changes following coronal suturectomy in craniosynostotic rabbits.
Cranial base changes following coronal suturectomy in craniosynostotic rabbits.
复制标题
颅缝早闭兔冠状缝切除术后颅底的变化。
DOI：
10.1034/j.1600-0544.2002.01178.x
复制
发表时间：
2002
影响因子：
3.1
通讯作者：
Mooney,MP
中科院分区：
文献类型：
--
作者：
Putz,DA;Smith,TD;Burrows,AM;Cooper,GM;Dechant,J;Losken,HW;Siegel,MI;Mooney,MP
手术松解颅缝可以改善颅缝早闭患者的各种颅底畸形。本研究的目的是测试这一假设在兔模型与家族性冠状缝骨性结合（CSS）。从56只新西兰白色家兔中收集数据：32只未受影响的对照组、11只未手术CSS组和13只25日龄时通过缝合切除术释放CSS组。 在第25、42和84天拍摄系列X线照片。 线性，角形和三角形颅底测量比较使用方差分析和张量生物统计学分析。结果显示，在84天时，与正常兔相比，两组CSS兔的前颅底长度和总颅底长度显著不同（p< 0.05），颅底角更平坦，前颅底形状畸形。 在有和没有缝合的CSS兔之间，仅在腭和颅底角以及后颅底形状方面观察到显著差异（p<0.05）。然而，在缝合切除术的CSS兔中，术后和术前测量的后颅底和总颅底长度以及前后颅底形状之间观察到显著（p< 0.05）变化。 结果显示，通过缝切除术手术松解骨性结合的冠状缝并不能使CSS兔的颅底生长模式正常化。这些发现可能是由于相对较晚的手术松解年龄或缝合部位再粘连伴持续畸形颅底生长。或者，CSS兔中观察到的颅底异常可能是早期原发性畸形，而不是继发性变形，需要手术矫正。
It has been suggested that surgical release of synostosed sutures may ameliorate various cranial base abnormalities in craniosynostotic patients. The present study was designed to test this hypothesis in a rabbit model with familial coronal suture synostosis (CSS). Data were collected from 56 New Zealand White rabbits: 32 unaffected controls, 11 with unoperated CSS, and 13 with CSS released by suturectomy performed at 25 days of age. Serial radiographs were taken at 25, 42 and 84 days. Linear, angular and triangular shape cranial base measurements were compared using ANOVA and tensor biometric analysis. Results revealed that at 84 days, both groups of CSS rabbits had significantly (p< 0.05) different anterior and total cranial base lengths, flatter cranial base angles, and dysmorphic anterior cranial base shapes when compared with normals. Significant (p< 0.05) differences were noted only for palatal and cranial base angles and posterior cranial base shape between CSS rabbits with and without suturectomy. However, significant (p< 0.05) changes were noted between pre‐ and post‐operative measurements in posterior and total cranial base lengths and anterior and posterior cranial base shapes in CSS rabbits with suturectomy. Results revealed that surgical release of synostosed coronal sutures through suturectomy did not normalize cranial base growth patterns in CSS rabbits. These findings may be explained by the relatively late age of surgical release or suturectomy site resynostosis with continued dysmorphic cranial base growth. Alternatively, cranial base abnormalities seen in CSS rabbits may be early primary malformations, not secondary deformations amenable to surgical modification.