Serum uric acid and incident diabetes in Mauritian Indian and Creole populations
Serum uric acid and incident diabetes in Mauritian Indian and Creole populations
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DOI：
10.1016/j.diabres.2008.01.002
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发表时间：
2008-05-01
影响因子：
5.1
通讯作者：
Tuomilehto, Jaakko
中科院分区：
文献类型：
--
作者：
Nan, Hairong;Qiao, Qing;Tuomilehto, Jaakko
目的：探讨血清尿酸（UA）对生活在毛里求斯的亚裔印度人和克里奥尔人患糖尿病的预测价值。方法：共纳入 1941 名男性（1409 名印度人、532 名克里奥尔人）和 2318 名非孕妇（1645 名印度人、673 名克里奥尔人），年龄 25-74 岁，基线检查时无糖尿病、心血管疾病和痛风。 1987年或1992年，1992年和/或1998年重新检查。根据WHO/IDF 2006标准确定糖尿病。使用间隔删失生存分析来评估基线 UA 与随访期间糖尿病发生之间的关系。结果：在该队列中，337 名 (17.4%) 男性和 379 名 (16.4%) 女性在随访期间患上糖尿病。与基线 UA 水平相比，在随访期间患上糖尿病的个体在随访时的血清 UA 水平较低，但绝经后妇女并未观察到这种情况。对应于 1 个 S.D. 的糖尿病发展的多变量调整风险比 (HR) (95% CI)印度男性基线 UA 浓度增加 1.14 (1.01, 1.30)，克里奥尔男性基线 UA 浓度增加 1.37 (1.11, 1.68)。在印度人和克里奥尔女性中，它们分别为 1.07 (0.95, 1.22) 和 1.01 (0.84, 1.22)。结论：血清 UA 升高是毛里求斯男性未来患糖尿病的独立风险标志物，而对女性的预测较弱。 (C) 2008 Elsevier Ireland Ltd. 保留所有权利。
Objective: To investigate the predictive value of serum uric acid (UA) for the development of diabetes in Asian Indians and Creoles living in Mauritius.Methods: A total of 1941 men (1409 Indians, 532 Creoles) and 2318 non-pregnant women (1645 Indians, 673 Creoles), aged 25-74years and free of diabetes, cardiovascular disease and gout at baseline examinations in 1987 or 1992, were re-examined in 1992 and/or 1998. Diabetes was determined according to WHO/IDF 2006 criteria. The relationship between baseline UA and the development of diabetes during the follow-up was estimated using interval censored survival analysis.Results: In this cohort 337 (17.4%) men and 379 (16.4%) women developed diabetes during the follow-up. Individuals who developed diabetes during the follow-up had a lower serum UA levels at follow-up compared with their baseline UA levels, but this is not observed for postmenopausal women. Multivariate adjusted hazard ratios (HRs) (95% CIs) for the development of diabetes corresponding to one S.D. increase in UA concentration at baseline were 1.14 (1.01, 1.30) in Indian men and 1.37 (1.11, 1.68) in Creole men. They were 1.07 (0.95, 1.22) and 1.01 (0.84, 1.22), respectively, in Indians and Creole women.Conclusion: Elevated serum UA is an independent risk marker for future diabetes in Mauritian men, whereas the prediction is weak in women. (C) 2008 Elsevier Ireland Ltd. All rights reserved.