Prospective Evaluation of the Reliability, Validity, and Minimally Important Difference of the Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) Quality-of-Life Instrument
Prospective Evaluation of the Reliability, Validity, and Minimally Important Difference of the Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) Quality-of-Life Instrument
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DOI：
10.1002/cncr.25556
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发表时间：
2011-03-15
期刊：
影响因子：
6.2
通讯作者：
Bathe, Oliver F.
中科院分区：
文献类型：
--
作者：
Garland, Sheila N.;Pelletier, Guy;Bathe, Oliver F.
背景：最近，人们开发了癌症治疗-胃功能评估(FACT-GA)来测量胃癌患者的生活质量。这个新开发的仪器还没有经过验证。方法：对82例胃腺癌患者进行基线问卷调查。FACTGA得分作为疾病阶段和表现状态的函数进行测量，并与医疗结果研究36项简明健康调查(SF-36)、贝克抑郁问卷-II、Marlow-Crowne社交合意量表、Paulhus欺骗量表和状态-特质焦虑问卷相关。患者在基线后2周接受第二次问卷调查，以评估重测信度，并在3个月时再次接受第二次问卷调查，以评估FACT-GA对绩效状态变化的敏感性，并估计代表有意义变化的分数中最小的重要差异。结果：FACT-GA量表具有良好的内部信度和重测信度。除了社会幸福感分量表外，所有的FACT-GA分数都与假设的其他测量相关。FACT-GA的相关组成部分对业绩状况的变化很敏感。结论：本研究结果表明，FACT-GA为胃腺癌患者提供了一种有效可靠的生活质量测量方法。它是临床试验中生活质量评估的有用工具，也可用于检测个体患者生活质量的显著变化。癌症杂志2011；117：1302-12。(C)2010年美国癌症协会
BACKGROUND: Recently, the Functional Assessment of Cancer Therapy-Gastric (FACT-Ga) was developed to measure the quality of life (QoL) of patients with gastric cancer. This newly developed instrument has not yet been validated. METHODS: Eighty-two patients with gastric adenocarcinoma completed questionnaires at baseline. The FACTGa scores were measured as a function of disease stage and performance status, and they were correlated with the Medical Outcomes Study 36-item short-form health survey (SF-36), the Beck Depression Inventory-II, the Marlow-Crowne Social Desirability Scale, the Paulhus Deception Scale, and the State-Trait Anxiety Inventory. Patients received a second questionnaire 2 weeks after baseline to evaluate test-retest reliability and again at 3 months to evaluate the sensitivity of the FACT-Ga to changes in performance status and to estimate the minimally important differences in scores that represented meaningful change. RESULTS: The internal and test-retest reliability of the FACT-Ga instrument was adequate. With the exception of the social well being subscale, all FACT-Ga scores were correlated as hypothesized with other measures. Relevant components of the FACT-Ga were sensitive to changes in performance status. CONCLUSIONS: The current results indicated that the FACT-Ga provides a valid and reliable measurement of QoL in patients with gastric adenocarcinoma. It is a useful instrument for QoL assessment in clinical trials, and it also may be useful for the detection of significant changes in the QoL of individual patients. Cancer 2011;117:1302-12. (C) 2010 American Cancer Society