Cellular factors which modulate hormone responses: glucocorticoid action in perspective.
Cellular factors which modulate hormone responses: glucocorticoid action in perspective.
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调节激素反应的细胞因素：糖皮质激素作用的视角。
DOI：
10.1016/b978-0-12-364376-6.50007-7
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Harrison3rd,RW
中科院分区：
文献类型：
--
作者：
Harrison3rd,RW
几乎所有糖皮质激素的作用都是通过基因转录的变化介导的。类固醇与受体的结合和类固醇-受体复合物的核结合是这一过程中的关键事件，但可能被特定类固醇穿过细胞膜或引起受体激活的能力所改变。受体的物理性质，其精确的亚细胞位置，以及完成基因激活的过程都是未知的。纯化受体的制备和核结合位点的进一步表征对于更好地理解这一过程至关重要。
Virtually all glucocorticoid effects are mediated through changes in gene transcription. Steroid binding to the receptor and nuclear binding of the steroid-receptor complex are pivotal events in this process, but may be modified by the ability of a given steroid to traverse the cell membrane or cause receptor activation. The physical nature of the receptor, its precise subcellular location, and the process by which gene activation is accomplished are unknown. Preparation of purified receptor and further characterization of the nuclear binding sites will be crucial to a better understanding of this process.