Effect of Endocrine Modifications and Pharmacological Treatments on Brain and Pituitary Concentrations of β- Endoirphin
Effect of Endocrine Modifications and Pharmacological Treatments on Brain and Pituitary Concentrations of β- Endoirphin
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内分泌调节和药物治疗对大脑和垂体 β-内啡肽浓度的影响
DOI：
10.1210/endo-107-1-245
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发表时间：
1980
期刊：
影响因子：
4.8
通讯作者：
H. G. Friesen
中科院分区：
文献类型：
--
作者：
S. Lee;A. Panerai;D. Bellabarba;H. G. Friesen
研究了不同年龄（8、24 和 60 天）大鼠大脑和垂体离散区域中 β-内啡肽的浓度。还研究了肾上腺切除术、睾丸切除术、卵巢切除术、甲状腺切除术和/或每天用 T4 治疗 1 个月后 1 个月的 β-内啡肽浓度。此外，还研究了吗啡、纳洛酮和戊巴比妥对大脑和垂体β-内啡肽浓度的急性影响。必要时，可通过凝胶色谱将 β-内啡肽免疫反应性与交叉反应化合物分离。 8 日龄和 24 日龄大鼠大脑区域的 β-内啡肽浓度相似，但在 24 日至 60 日龄期间显着增加。肾上腺切除后，垂体、后脑、中脑和下丘脑中 β-内啡肽的浓度显着增加。甲状腺切除术后，下丘脑中β-内啡肽的浓度显着增加。观察到垂体中β-内啡肽浓度显着降低......
The concentrations of β-endorphin in discrete regions of the rat brain and pituitary were studied at different ages (8, 24, and 60 days). β-Endorphin concentrations have also been studied 1 month after adrenalectomy, orchiectomy, ovariectomy, thyroidectomy, and/or daily treatment with T4 for 1 month. Moreover, the acute effects of morphine, naloxone, and pentobarbital on brain and pituitary concentrations of β-endorphin have been studied. When necessary, β-endorphin immunoreactivity has been separated from cross-reacting compounds by gel chromatography. The concentrations of β-endorphin in rat brain regions were similar in 8- and 24-day-old rats but increased significantly between days 24 and 60. After adrenalectomy, the concentration of β-endorphin increased significantly in the pituitary, hindbrain, midbrain, and hypothalamus. After thyroidectomy, the concentration of β-endorphin increased significantly in the hypothalamus. A significant decrease in β-endorphin concentration in the pituitary was observe...