Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment.
Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment.
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DOI：
10.3109/02656736.2013.825014
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发表时间：
2013-12
期刊：
影响因子：
--
通讯作者：
Hoopes PJ
中科院分区：
文献类型：
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作者：
Petryk AA;Giustini AJ;Gottesman RE;Kaufman PA;Hoopes PJ
本研究的目的是研究磁性纳米粒子热疗（mNPH）联合顺铂全身化疗在小鼠乳腺癌模型（MTGB）中的治疗效果。使用交变磁场（在165 kHz下为35.8 kA/m）在43 °C下将110 nm羟乙基淀粉涂覆的磁性纳米颗粒（mNP）活化至60 min的热剂量。肿瘤内mNP以7.5mg Fe/cm 3肿瘤（四个相等的肿瘤象限）递送。在mNPH之前1小时，腹膜内给予5 mg/kg体重的顺铂。肿瘤再生长延迟时间用于评估治疗效果。mNP热疗联合顺铂的效果是单独mNP热疗的1.7倍，是单独顺铂的1.4倍（p<0.05）。我们的研究结果表明，mNP热疗可以导致顺铂癌症治疗的安全和显着的治疗增强。
The purpose of this study was to examine the therapeutic effect of magnetic nanoparticle hyperthermia (mNPH) combined with systemic cisplatin chemotherapy in a murine mammary adenocarcinoma model (MTGB). An alternating magnetic field (35.8 kA/m at 165 kHz) was used to activate 110 nm hydroxyethyl starch-coated magnetic nanoparticles (mNP) to a thermal dose of 60 min at 43 °C. Intratumoral mNP were delivered at 7.5 mg of Fe/cm3 of tumour (four equal tumour quadrants). Intraperitoneal cisplatin at 5 mg/kg body weight was administered 1 h prior to mNPH. Tumour regrowth delay time was used to assess the treatment efficacy. mNP hyperthermia, combined with cisplatin, was 1.7 times more effective than mNP hyperthermia alone and 1.4 times more effective than cisplatin alone (p<0.05). Our results demonstrate that mNP hyperthermia can result in a safe and significant therapeutic enhancement for cisplatin cancer therapy.