Synthesis and characterization of two self-assembled [Cu6Gd3] and [Cu5Dy2] complexes exhibiting the magnetocaloric effect, slow relaxation of magnetization, and anticancer activity.
Synthesis and characterization of two self-assembled [Cu6Gd3] and [Cu5Dy2] complexes exhibiting the magnetocaloric effect, slow relaxation of magnetization, and anticancer activity.
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两种自组装 [Cu6Gd3] 和 [Cu5Dy2] 配合物的合成和表征，表现出磁热效应、磁化缓慢弛豫和抗癌活性。
DOI：
10.1039/d2dt03932j
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Bhanja A
中科院分区：
文献类型：
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作者：
Bhanja A
以Cu（ClO 4）2·6 H2O、NEt 3和GdCl 3/DyCl 3·6 H2O为配位驱动的自组装反应体系，在2-（（1-羟基-2-甲基丙-2-亚氨基）甲基）-6-甲氧基苯酚（H2 L）的支持下，发现了两条新的配位驱动自组装反应路径. 类似的合成方案可用于提供两种不同类型的自聚集分子簇[Cu 6 Gd 3（L）3（HL）3（μ3-Cl）3（μ3-OH）6（OH）2] ClO 4·4 H2O（1）和[Cu 5Dy 2（L）2（HL）2（μ-Cl）2（μ3-OH）4（ClO 4）2（H2O）6]（ClO 4）2·2NHEt 3Cl·21 H2O（2）。所采用的反应程序确定了HO−和Cl−离子在来自溶剂和金属离子盐的络合物的矿物样生长中的重要性。在配合物1中，一个Gd III中心被捕获在由六个μ3-OH和三个μ3-Cl基团支撑的核心的中心位置，而对于配合物2，一个Cu II中心被捕获使用四个μ3-羟基和两个μ-氯基。1的磁热行为已被检查为磁热效应−ΔSm = 11.3 J kg−1 K−1，在2 K，ΔH = 7 T，而磁化率测量2显示出缓慢的磁弛豫，Ueff = 15.8 K和τ0 = 9.8 × 10−7 s在零外部直流场。癌细胞生长抑制研究证明了这两种复合物对人肺癌细胞具有有趣的高活性的潜力。配合物1和2也表现出DNA和人血清白蛋白（HSA）的结合能力，涉及的结合位点和热力学。
Two new paths for coordination driven self-assembly reactions under the binding support of 2-((1-hydroxy-2-methylpropan-2-ylimino)methyl)-6-methoxyphenol (H2L) have been discovered from the reactions of Cu(ClO4)2·6H2O, NEt3 and GdCl3/DyCl3·6H2O in MeOH/CHCl3 (2 : 1) medium. A similar synthetic protocol is useful to provide two different types of self-aggregated molecular clusters [Cu6Gd3(L)3(HL)3(μ3-Cl)3(μ3-OH)6(OH)2]ClO4·4H2O (1) and [Cu5Dy2(L)2(HL)2(μ-Cl)2(μ3-OH)4(ClO4)2(H2O)6](ClO4)2·2NHEt3Cl·21H2O (2). The adopted reaction procedure established the importance of the HO− and Cl− ions in the mineral-like growth of the complexes, derived from solvents and metal ion salts. In the case of complex 1, one GdIII center has been trapped at the central position of the core upheld by six μ3-OH and three μ3-Cl groups, whereas for complex 2 one CuII center was trapped using four μ3-hydroxo and two μ-chlorido groups. The magnetothermal behavior of 1 has been examined for a magnetocaloric effect of −ΔSm = 11.3 J kg−1 K−1 at 2 K for ΔH = 7 T, whereas the magnetic susceptibility measurements of 2 showed slow magnetic relaxation with Ueff = 15.8 K and τ0 = 9.8 × 10−7 s in zero external dc field. Cancer cell growth inhibition studies proved the potential of both the complexes with interestingly high activity for the Cu6Gd3 complex against human lung cancer cells. Both complexes 1 and 2 also exhibited DNA and human serum albumin (HSA) binding abilities in relation to the involved binding sites and thermodynamics.