Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure
Molecular basis for the improvement in muscle metaboreflex and mechanoreflex control in exercise-trained humans with chronic heart failure
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DOI：
10.1152/ajpheart.00136.2014
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发表时间：
2014-12-01
影响因子：
4.8
通讯作者：
Negrao, Carlos E.
中科院分区：
文献类型：
--
作者：
Antunes-Correa, Ligia M.;Nobre, Thais S.;Negrao, Carlos E.
以往的研究表明，心力衰竭（HF）时肌肉机械反射和代谢反射的控制发生改变，这似乎是由于环氧合酶（考克斯）通路的变化和传入神经元上受体的变化，包括瞬时受体电位香草素1型（TRPV 1）和大麻素受体1型（CB 1）。本研究的目的是验证以下假设：1）运动训练（ET）改变HF患者肌肉交感神经活动（MSNA）的肌肉代谢反射和机械反射控制。2)代谢反射控制的改变伴随着骨骼肌中TRPV 1和CB 1受体表达的增加。3)骨骼肌中机械反射控制的改变伴随着考克斯-2通路。34例射血分数的连续HF患者
Previous studies have demonstrated that muscle mechanoreflex and metaboreflex controls are altered in heart failure (HF), which seems to be due to changes in cyclooxygenase (COX) pathway and changes in receptors on afferent neurons, including transient receptor potential vanilloid type-1 (TRPV1) and cannabinoid receptor type-1 (CB1). The purpose of the present study was to test the hypotheses: 1) exercise training (ET) alters the muscle metaboreflex and mechanoreflex control of muscle sympathetic nerve activity (MSNA) in HF patients. 2) The alteration in metaboreflex control is accompanied by increased expression of TRPV1 and CB1 receptors in skeletal muscle. 3) The alteration in mechanoreflex control is accompanied by COX-2 pathway in skeletal muscle. Thirty-four consecutive HF patients with ejection fractions