The multi-functional eyes absent proteins.
The multi-functional eyes absent proteins.
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DOI：
10.1080/10409238.2020.1796922
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发表时间：
2020-08
影响因子：
6.5
通讯作者：
Pandey RN
中科院分区：
文献类型：
--
作者：
Hegde RS;Roychoudhury K;Pandey RN
Eyes Absent（EYA）蛋白是唯一已知的具有以下三种可分离的生物化学活性的单一多肽的实例：酪氨酸磷酸酶、苏氨酸磷酸酶和反式激活。这使EYA独特地参与转录调节和信号转导途径。但它也使通过标准的功能丧失实验将生物作用分配给个体生化活动变得复杂。然而，有一个新兴的文献将发育和病理功能与各种EYA活动联系起来，并且越来越多的疾病状态可能受益于EYA靶向治疗。还有许多尚未解决的问题，对我们理解EYAs如何影响MYC和Notch途径等普遍存在的信号级联具有重要意义。受EYA酪氨酸磷酸酶活性影响的底物和信号传导途径EYA酪氨酸磷酸酶活性信号传导途径的调节模式涉及EYA的苏氨酸磷酸酶活性，包括与PP 2A-B55 α的潜在相互作用、两种磷酸酶活性之间的相互作用以及与EYA相关的EYA疾病状态的反式激活功能和EYA的当前发展状态。靶向治疗。这篇综述将描述EYA中生化活性的独特并列，它们与信号通路和细胞过程的相互作用，疾病状态中作用的新证据，以及个体EYA活性治疗靶向的可行性。我们将专注于脊椎动物EYA蛋白的磷酸酶活性，并将研究有关以下方面的知识现状：
The Eyes Absent (EYA) proteins are the only known instance of a single polypeptide housing the following three separable biochemical activities: tyrosine phosphatase, threonine phosphatase, and transactivation. This uniquely positions the EYAs to participate in both transcriptional regulation and signal transduction pathways. But it also complicates the assignment of biological roles to individual biochemical activities through standard loss-of-function experiments. Nevertheless, there is an emerging literature linking developmental and pathological functions with the various EYA activities, and a growing list of disease states that might benefit from EYA-targeted therapeutics. There also remain multiple unresolved issues with significant implications for our understanding of how the EYAs might impact such ubiquitous signaling cascades as the MYC and Notch pathways. substrates and signaling pathways affected by the EYA tyrosine phosphatase activity modes of regulation of the EYA tyrosine phosphatase activity signaling pathways that implicate the threonine phosphatase activity of the EYAs including a potential interaction with PP2A-B55α the interplay between the two phosphatase activities and the transactivation function of the EYAs disease states associated with the EYAs and the current state of development of EYA-targeted therapeutics. This review will describe the unique juxtaposition of biochemical activities in the EYAs, their interaction with signaling pathways and cellular processes, emerging evidence of roles in disease states, and the feasibility of therapeutic targeting of individual EYA activities. We will focus on the phosphatase activities of the vertebrate EYA proteins and will examine the current state of knowledge regarding:
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影响因子：
21.3
作者：
Gohla, A;Birkenfeld, J;Bokoch, GM
通讯作者：
Bokoch, GM
DOI：
10.4161/cc.26755
发表时间：
2014
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Kohrt D;Crary J;Zimmer M;Patrick AN;Ford HL;Hinds PW;Grossel MJ
通讯作者：
Grossel MJ
影响因子：
4.8
作者：
Krishnan, Navasona;Jeong, Dae Gwin;Tonks, Nicholas K.
通讯作者：
Tonks, Nicholas K.
影响因子：
64.8
作者：
Li, X;Oghi, KA;Rosenfeld, MG
通讯作者：
Rosenfeld, MG
影响因子：
11.8
作者：
Eisner A;Pazyra-Murphy MF;Durresi E;Zhou P;Zhao X;Chadwick EC;Xu PX;Hillman RT;Scott MP;Greenberg ME;Segal RA
通讯作者：
Segal RA