A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint.
A Cell Biological Perspective on Past, Present and Future Investigations of the Spindle Assembly Checkpoint.
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DOI：
10.3390/biology5040044
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发表时间：
2016-11-19
期刊：
影响因子：
4.2
通讯作者：
Joglekar AP
中科院分区：
文献类型：
--
作者：
Joglekar AP
纺锤体组装检查点（SAC）是一种质量控制机制，可确保细胞分裂过程中染色体的准确分离。它由感知染色体与纺锤体附着的机械化学信号传导机制和如果一条或多条染色体未附着则抑制细胞分裂的信号级联反应组成。广泛的调查，这两个组成系统的SAC合成了一个全面的理解的基本分子机制。这篇评论叙述了阐明SAC的里程碑式的结果，编译了一个简单的模型的复杂的分子机制的SAC，并强调了不了解的方面的生化设计和细胞生物学操作的SAC，将推动研究在不久的将来。
The spindle assembly checkpoint (SAC) is a quality control mechanism that ensures accurate chromosome segregation during cell division. It consists of a mechanochemical signal transduction mechanism that senses the attachment of chromosomes to the spindle, and a signaling cascade that inhibits cell division if one or more chromosomes are not attached. Extensive investigations of both these component systems of the SAC have synthesized a comprehensive understanding of the underlying molecular mechanisms. This review recounts the milestone results that elucidated the SAC, compiles a simple model of the complex molecular machinery underlying the SAC, and highlights poorly understood facets of the biochemical design and cell biological operation of the SAC that will drive research forward in the near future.