Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity.
Rostral anterior cingulate cortex activity mediates the relationship between the depressive symptoms and the medial prefrontal cortex activity.
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DOI：
10.1016/j.jad.2009.06.017
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发表时间：
2010-04
影响因子：
6.6
通讯作者：
Shinpei Yoshimura;Y. Okamoto;K. Onoda;M. Matsunaga;K. Ueda;Shin-ichi Suzuki;Shigetoyamawaki
中科院分区：
文献类型：
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作者：
Shinpei Yoshimura;Y. Okamoto;K. Onoda;M. Matsunaga;K. Ueda;Shin-ichi Suzuki;Shigetoyamawaki
抑郁症的特征是对负面情绪刺激的自我参照处理增强。影像学研究表明，内侧前额叶（MPFC）和前扣带皮层（ACC）的激活与自我参照加工有关。然而，这种激活模式是否发生在抑郁症患者的自我参照过程中的情绪stimulations.METHODS参与者的情绪stimulations.MethodsParticipants是13例重性抑郁症患者和13名正常对照。本研究采用功能磁共振成像（fMRI）技术，观察了抑郁症患者在自我参照判断正、负配价人格特征词时的神经活动。结果：与正常对照组相比，抑郁症患者在自我参照判断负配价人格特征词时，MPFC和前扣带回的头端活动明显增强。此外，这些区域在负性刺激的自我参照加工过程中的活动与抑郁症状的严重程度相关。MPFC活性与抑郁症状之间的相关性是由ACC的头端活性介导的。功能连接分析揭示了MPFC，吻侧ACC和杏仁核之间的正连接性。LIMITATIONSmall N和抗抑郁作用的成像数据限制了稳定性的报告findings.CONCLUSIONSThe之间的关系MPFC，吻侧ACC，杏仁核似乎反映了自我参照处理和负面情绪信息处理之间的相互作用，我们认为MPFC和前扣带回吻侧之间的紧密联系与抑郁症状有关。
BACKGROUNDDepression is characterized by enhanced self-referential processing of negative emotional stimuli. Imaging studies have suggested that activation of both the medial prefrontal (MPFC) and anterior cingulate cortices (ACC) is associated with self-referential processing. However, whether this pattern of activation occurs in depressed individuals during the self-referential processing of the emotional stimuli had not been investigated to date.METHODSParticipants were 13 patients with major depressive disorder and 13 normal controls. We used block-designed functional magnetic resonance imaging (fMRI) to investigate neural activity during the self-referential judgments of positive and negative valenced personality trait words.RESULTSCompared with the normal controls, the depressed patients showed hyperactivity in the MPFC and the rostral ACC during the self-referential processing of negative words. In addition, the activity of these regions during self-referential processing of the negative stimuli was correlated with the depressive symptom severity. The rostral ACC activity mediated the correlation between the MPFC activity and the depressive symptoms. Functional connectivity analysis revealed positive connectivities between the MPFC, the rostral ACC, and the amygdala.LIMITATIONSmall N and antidepressant effect on imaging data limit the stability of reported findings.CONCLUSIONSThe relationships between the MPFC, the rostral ACC, and the amygdala appear to reflect an interaction between the self-referential processing and the negative emotional information processing, and we propose that the strong connection between the MPFC and the rostral ACC is associated with depressive symptoms.