Central adrenomedullin augments the baroreceptor reflex ire conscious rabbits
Central adrenomedullin augments the baroreceptor reflex ire conscious rabbits
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DOI：
10.1161/01.hyp.33.4.992
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发表时间：
1999-04-01
期刊：
影响因子：
8.3
通讯作者：
Fujishima, M
中科院分区：
文献类型：
--
作者：
Matsumura, K;Abe, I;Fujishima, M
我们研究了中枢肾上腺髓质素、肾上腺髓质素前n端20肽（PAMP）和降钙素基因相关肽（CGRP）在清醒家兔压力受体反射中的作用。脑室内注射肾上腺髓质素（0.2和nmol/80 μ L）引起动脉压和肾交感神经活动的剂量相关升高。另一方面，与载药输注相比，脑室内注射亚压剂量的肾上腺髓质素（1 nmol/300 μ L /小时）引起肾交感神经活动和心率评估的压力反射敏感性显著增加(G(max)；-14.9 +/- 1.7 vs -8.0 +/- 0.7%/mm Hg, P < 0.01, -8.1 +/- 0.8 vs -5.1 +/- 0.5 bpm/mm Hg, P < 0.01)。脑室内灌注CGRP (1 nmol/300 μ L / h)，其结构与肾上腺髓质素相似，也增强了肾交感神经活动和心率的压力反射控制。然而，脑室内灌注PAMP （30 nmol/300 μ L /小时）未能改变动脉压和压力反射敏感性的基线水平。这些结果表明，中枢肾上腺髓质素和CGRP参与心血管调节，增强肾交感神经活动和心率的压力反射控制，而不是PAMP。
We examined the roles of central adrenomedullin, proadrenomedullin N-terminal 20 peptide (PAMP), and calcitonin gene-related peptide (CGRP) on the baroreceptor reflex in conscious rabbits. Intracerebroventricular injection of adrenomedullin (0.2 and nmol/80 mu L) elicited dose-related increases in arterial pressure and renal sympathetic nerve activity. On the other hand, a subpressor dose of intracerebroventricular infusion of adrenomedullin (1 nmol/300 mu L per hour) caused significant increases in baroreflex sensitivities assessed by renal sympathetic nerve activity and heart rate compared with vehicle infusion (G(max); -14.9 +/- 1.7 versus -8.0 +/- 0.7%/mm Hg, P < 0.01, and -8.1 +/- 0.8 versus -5.1 +/- 0.5 bpm/mm Hg, P < 0.01, respectively). Intracerebroventricular infusion of CGRP (1 nmol/300 mu L per hour), which is structurally homologous to adrenomedullin, also enhanced the baroreflex controls of renal sympathetic nerve activity and heart rate. However, the intracerebroventricular infusion of PAMP (30 nmol/300 mu L per hour) failed to alter the baseline levels of arterial pressure and baroreflex sensitivities. These results suggest that central adrenomedullin and CGRP, but not PAMP, participate in cardiovascular regulation to augment the baroreflex controls of renal sympathetic nerve activity and heart rate in conscious rabbits.