Association of daily sleep duration with the incident dementia by serum soluble <scp>TREM2</scp> in a community
Association of daily sleep duration with the incident dementia by serum soluble <scp>TREM2</scp> in a community
复制标题
社区中血清可溶性 <scp>TREM2</scp> 每日睡眠时间与痴呆事件的关联
DOI：
10.1111/jgs.17634
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发表时间：
2021
影响因子：
6.3
通讯作者：
Ninomiya Toshiharu
中科院分区：
文献类型：
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作者：
Ohara Tomoyuki;Hata Jun;Tanaka Masashi;Honda Takanori;Yamakage Hajime;Inoue Takayuki;Hirakawa Yoichiro;Kusakabe Toru;Shibata Mao;Kitazono Takanari;Nakao Tomohiro;Satoh‐Asahara Noriko;Ninomiya Toshiharu
背景骨髓细胞表达可溶性触发受体2（sTREM 2）是一种可溶性的先天免疫受体，表达于小胶质细胞上，每日睡眠时间与痴呆症风险之间的关系。方法前瞻性随访了10年，共1230名60岁及以上无痴呆症的日本社区居民（2002-2012年）。使用中值（334.8pg/ml）将血清sTREM 2水平分为两组。自我报告的每日睡眠时间分为三个类别：<5.0，5.0-7.9和≥8.0小时。采用考克斯比例风险模型，根据血清sTREM 2水平估计每日睡眠时间对痴呆风险的风险比（HR）及其95%置信区间（CI）。在血清sTREM 2水平低的受试者中，每日睡眠≥8.0 h的受试者发生痴呆的风险显著高于每日睡眠5.0-7.9 h的受试者（多变量调整HR 2.05 [95% CI 1.32-3.19]），但<5.0 h的受试者则无此风险。相比之下，在血清sTREM 2水平较高的受试者中，每日睡眠时间<5.0 h（1.95 [1.03-3.68]）和≥8.0 h（1.48 [1.06-2.07]）的受试者患痴呆症的风险显著增加。每日睡眠时间短可能仅在血清sTREM 2水平高的受试者中与痴呆症风险增加相关。
BackgroundLittle is known about the influence of serum level of soluble triggering receptor expressed on myeloid cells 2 (sTREM2), which is a soluble type of an innate immune receptor expressed on the microglia, on the association of the daily sleep duration with the risk of dementia.MethodsA total of 1230 Japanese community‐residents aged 60 and older without dementia were followed prospectively for 10 years (2002–2012). Serum sTREM2 levels were divided into two groups using the median value (334.8 pg/ml). Self‐reported daily sleep duration was grouped into three categories of <5.0, 5.0–7.9, and ≥8.0 h. A Cox proportional hazards model was used to estimate the hazard ratios (HRs) and their 95% confidence intervals (CIs) of daily sleep duration on the risk of dementia according to serum sTREM2 levels.ResultsDuring the follow‐up, 262 subjects developed dementia. In subjects with low serum sTREM2 levels, subjects with ≥8.0 h of daily sleep had a significantly greater risk of dementia (multivariable‐adjusted HR 2.05 [95% CI 1.32–3.19]) than those with 5.0–7.9 h of daily sleep, but those with <5.0 h did not. In contrast, the risk of dementia increased significantly in subjects with both <5.0 (1.95 [1.03–3.68]) and ≥8.0 h of daily sleep (1.48 [1.06–2.07]) in the subjects with high serum sTREM2 levels.ConclusionsThe influence of daily sleep duration on risk of dementia differed according to serum sTREM2 levels in the older Japanese population. Short daily sleep may be associated with greater risk of dementia only in subjects with a high serum sTREM2 level.