Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase
Virus replication inhibitory peptide inhibits the conversion of phospholipid bilayers to the hexagonal phase
复制标题
病毒复制抑制肽抑制磷脂双层向六角相的转化
DOI：
10.1007/bf01114759
复制
发表时间：
1986
影响因子：
4
通讯作者：
R. Epand
中科院分区：
文献类型：
--
作者：
R. Epand
病毒复制抑制肽（苯甲氧基-D-Phe-L-PheGly）被证明是副粘病毒和粘病毒复制的有效特异性抑制剂（Richardson，Scheid 和 Choppin (1980)，Virology105, 205–222）。该肽抑制病毒糖蛋白的膜融合活性。许多促进膜中六方相形成的试剂也加速膜融合。在摩尔分数为0.1的情况下，病毒复制抑制肽可以将二油酰磷脂酰乙醇胺的双层到六角形的相变温度提高近10°。两种相关的肽，苯甲氧基-L-PheGly 和苯甲氧基-L-GlyPhe，在提高双层至六方相变温度方面的效力较差，后一种肽是三者中效果最差的。该效力顺序与抑制病毒复制的效力顺序相同。抑制纯脂质六方相形成的物质也可能抑制膜融合。
Virus replication inhibitory peptide (carbobenzoxy-D-Phe-L-PheGly) was shown to be a potent specific inhibitor of the replication of paramyxovirus and myxovirus (Richardson, Scheid and Choppin (1980), Virology105, 205–222). This peptide inhibits the membrane fusing activity of a viral glycoprotein.Many agents which promote the formation of the hexagonal phase in membranes also accelerate membrane fusion. At a mole fraction of 0.1, viral replication inhibitory peptide can raise the bilayer to hexagonal phase transition temperature of dielaidoylphosphatidylethanolamine by almost 10°. Two related peptides, carbobenzoxy-L-PheGly and carbobenzoxy-L-GlyPhe, are less potent in raising the bilayer to hexagonal phase transition temperature, with the latter peptide being the least effective of the three. This order of potency is the same as the order of potency in inhibiting viral replication. Substances which inhibit hexagonal phase formation of pure lipids may also inhibit membrane fusion.