PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy.
PD-1 regulates T cell proliferation in a tissue and subset-specific manner during normal mouse pregnancy.
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DOI：
10.3109/08820139.2013.782317
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发表时间：
2013
影响因子：
2.8
通讯作者：
Bonney EA
中科院分区：
文献类型：
--
作者：
Shepard MT;Bonney EA
妊娠期间T细胞稳态的调节对母体耐受和免疫具有重要意义。有证据表明，程序性死亡-1（PD-1）参与调节T细胞稳态和外周耐受。为了检查PD-1信号传导对正常小鼠妊娠期间T细胞稳态的贡献，我们在妊娠第10、12和14天给予抗PD-1阻断抗体或对照的妊娠小鼠中通过流式细胞术、BrdU掺入和TUNEL测定来检查T细胞数量或比例、PD-1表达、增殖和凋亡。我们观察了PD-1表达的组织、治疗和T细胞特异性差异。妊娠和PD-1阻断均增加脾脏中的T细胞增殖，而这种作用仅限于子宫引流结中的CD 4 T细胞。在子宫中，PD-1阻断显著改变了T细胞池的组成。这些研究支持妊娠是一种动态T细胞稳态状态的观点，并表明这种状态部分受到PD-1信号的支持。
The regulation of T cell homeostasis during pregnancy has important implications for maternal tolerance and immunity. Evidence suggests that Programmed Death-1 (PD-1) participates in regulation of T cell homeostasis and peripheral tolerance. To examine the contribution of PD-1 signaling on T cell homeostasis during normal mouse pregnancy, we examined T cell number or proportion, PD-1 expression, proliferation, and apoptosis by flow cytometry, BrdU incorporation, and TUNEL assay in pregnant mice given anti-PD-1 blocking antibody or control on days 10, 12, and 14 of gestation. We observed tissue, treatment, and T cell-specific differences in PD-1 expression. Both pregnancy and PD-1 blockade increased T cell proliferation in the spleen while this effect was limited to CD4 T cells in the uterine- draining nodes. In the uterus, PD-1 blockade markedly altered the composition of the T cell pool. These studies support the idea that pregnancy is a state of dynamic T cell homeostasis and suggest that this state is partially supported by PD-1 signaling.
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DOI：
10.4049/jimmunol.0800997
发表时间：
2009-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Bucks CM;Norton JA;Boesteanu AC;Mueller YM;Katsikis PD
通讯作者：
Katsikis PD
影响因子：
30.5
作者：
Blackburn, Shawn D.;Shin, Haina;Haining, W. Nicholas;Zou, Tao;Workman, Creg J.;Polley, Antonio;Betts, Michael R.;Freeman, Gordon J.;Vignali, Dario A. A.;Wherry, E. John
通讯作者：
Wherry, E. John
凋亡调节因子 Fas 和 Bim 协同控制 T 淋巴细胞稳态增殖。
影响因子：
5.4
作者：
Fortner, Karen A.;Bouillet, Philippe;Strasser, Andreas;Budd, Ralph C.
通讯作者：
Budd, Ralph C.
DOI：
10.1073/pnas.192461099
发表时间：
2002-09-17
影响因子：
11.1
作者：
Iwai, Y;Ishida, M;Minato, N
通讯作者：
Minato, N
影响因子：
64.8
作者：
Day, Cheryl L.;Kaufmann, Daniel E.;Walker, Bruce D.
通讯作者：
Walker, Bruce D.