Effects of Chronic Central Arginine Vasopressin (AVP) on Maternal Behavior in Chronically Stressed Rat Dams
Effects of Chronic Central Arginine Vasopressin (AVP) on Maternal Behavior in Chronically Stressed Rat Dams
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DOI：
10.3390/brainsci2040589
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发表时间：
2012-12-01
期刊：
影响因子：
3.3
通讯作者：
Nephew, Benjamin C.
中科院分区：
文献类型：
--
作者：
Coverdill, Alexander J.;McCarthy, Megan;Nephew, Benjamin C.
母亲在怀孕期间或产后期间暴露于慢性压力源通常会导致抑郁，焦虑或其他相关情绪障碍的发展。情绪障碍的不良影响往往是通过母性行为介导的，最近的工作已经确定精氨酸加压素（AVP）作为一个关键的神经肽激素在大鼠和人类的母性行为的表达。使用建立的啮齿动物模型，elephants行为和生理反应类似于人类的情绪障碍，本研究测试的有效性，慢性AVP输注作为一种新的治疗暴露于慢性社会压力的不利影响在哺乳期大鼠。在早期（第3天）和中期（第10天）哺乳期，AVP治疗显着减少了潜伏期开始护理和时间花费检索幼崽，并增加幼崽梳理和总的母亲护理（幼崽梳理和护理的总和）。AVP治疗也有效地减少母亲的侵略性和侵略性发作的平均持续时间在哺乳期第3天。中枢AVP可能是一个有效的目标，为发展的治疗，以提高产妇的行为在个人暴露于慢性社会压力。
Exposure of mothers to chronic stressors during pregnancy or the postpartum period often leads to the development of depression, anxiety, or other related mood disorders. The adverse effects of mood disorders are often mediated through maternal behavior and recent work has identified arginine vasopressin (AVP) as a key neuropeptide hormone in the expression of maternal behavior in both rats and humans. Using an established rodent model that elicits behavioral and physiological responses similar to human mood disorders, this study tested the effectiveness of chronic AVP infusion as a novel treatment for the adverse effects of exposure to chronic social stress during lactation in rats. During early (day 3) and mid (day 10) lactation, AVP treatment significantly decreased the latency to initiate nursing and time spent retrieving pups, and increased pup grooming and total maternal care (sum of pup grooming and nursing). AVP treatment was also effective in decreasing maternal aggression and the average duration of aggressive bouts on day 3 of lactation. Central AVP may be an effective target for the development of treatments for enhancing maternal behavior in individuals exposed to chronic social stress.