Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1-3 Colon Cancer: A Meta-Analysis
Oncologic Effects of Primary Tumor-Sidedness on Patients with Stages 1-3 Colon Cancer: A Meta-Analysis
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DOI：
10.1245/s10434-019-07164-7
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发表时间：
2019-05-01
影响因子：
3.7
通讯作者：
Lee, Min Ro
中科院分区：
文献类型：
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作者：
Ha, Gi Won;Kim, Jong Hun;Lee, Min Ro
背景以前的研究比较了原发性肿瘤侧结肠癌患者的肿瘤学结局，报道了右侧肿瘤患者的预后更差。然而，这些研究中的大多数评估了转移性疾病的患者。在PubMed、EMBASE和科克伦图书馆中检索评估原发肿瘤侧性对1、2和3期结肠癌患者生存结局影响的研究。评估原发肿瘤部位对总生存期（OS）、癌症特异性生存期（CSS）和无病生存期（DFS）的风险比（HR）。37项研究符合纳入标准，涉及581，542例患者。右侧肿瘤患者的CSS更好（HR，0.67; 95%置信区间[CI]，0.56-0.80; p
Background. Previous studies comparing the oncologic outcomes of primary tumor-sidedness for patients with colon cancer have reported a worse prognosis for those with right-sided tumors. However, most of these studies evaluated patients with metastatic disease.Methods. PubMed, EMBASE, and the Cochrane Library were searched for studies that assessed the effects of primary tumor-sidedness on survival outcomes for patients with stages 1, 2, and 3 colon cancer. The hazard ratio (HR) for primary tumor location was estimated for overall survival (OS), cancer-specific survival (CSS) and disease-free survival (DFS).Results. The inclusion criteria were met by 37 studies involving 581,542 patients. The patients with a right-sided tumor had better CSS (HR, 0.67; 95% confidence interval [CI], 0.56-0.80; p