Assessment of allergic hypersensitivity to dental materials
Assessment of allergic hypersensitivity to dental materials
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DOI：
10.3233/bme-2009-0563
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发表时间：
2009-01-01
影响因子：
1
通讯作者：
Nishigawa, Keisuke
中科院分区：
文献类型：
--
作者：
Hosoki, Maki;Bando, Eiichi;Nishigawa, Keisuke
义齿中的某些金属材料可能会引起过敏性超敏反应。症状不仅出现在口腔中，也出现在手，脚或整个身体上。金属离子的释放被认为会引起过敏反应;金属和/或离子金属氢氧化物/氧化物的腐蚀产物的微粒可能是过敏原。本研究旨在回顾本院口腔科过敏性反应的临床监测。从2000年7月至2005年6月，212例疑似牙齿金属过敏的患者使用26种试剂进行斑贴试验，包括19种现成的斑贴试验试剂（斑贴试验试剂T，Torii Pharmaceutical Corporation，Tokyo，Japan）和9种定制试剂。167例患者为女性（78.8%），45例患者为男性（21.2%）。共有148例患者（69.8%）出现一次或多次阳性斑贴试验反应。最常见的过敏原是镍（25.0%）、钯（24.4%）、铬（16.7%）、钴（15.9%）和锡（12.5%）。典型的过敏症状和诊断为掌跖脓疱病、扁平苔藓、口腔炎和接触性皮炎。这项研究表明，牙科医生和牙科研究人员应该关注牙科金属材料的致敏潜力。
Some metallic materials in dental prostheses may cause allergic hypersensitivity. Symptoms appear not only in the oral cavity, but also on hands, feet or the entire body. Release of metal ions is thought to cause the allergic reactions; micro-particles of the corrosion products of the metal and/or ionic metal hydroxides/oxides may be the allergens. The study purpose was to review clinical surveillance of dental allergic hypersensitivity in our dental hospital. From July 2000 to June 2005, 212 patients with suspected dental metal allergy were patch tested with 26 reagents, including 19 ready-made patch test reagents (Patch test reagents T, Torii Pharmaceutical Corporation, Tokyo, Japan) and 9 custom-made reagents. One-hundredand-sixty-seven patients were females (78.8%) and 45 patients were males (21.2%). A total of 148 patients (69.8%) had one or more positive patch test reactions. The most common allergens were nickel (25.0%), palladium (24.4%), chromium (16.7%), cobalt (15.9%) and stannum (12.5%). Typical allergic symptoms and diagnoses were Pustulosis palmaris et plantaris, lichen planus, stomatitis and contact dermatitis. This study indicates that dentists and dental researchers should be concerned about the allergenic potential of dental metal materials.